A Cross-sectional Study of Clinical, Histopathological and Direct Immunofluorescence Spectrum of Vesiculobullous Disorders
Background: Accurate diagnosis of vesiculobullous lesions of skin requires evaluation of clinical, histopathologic and immunofluorescence findings. Methods: A cross-sectional study of 68 patients to evaluate the clinical, histopathological and direct immunofluorescence (DIF) features in the dia...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3760/36-%207019_E(C)_F(T)_PF1(PP)_PFA(H).pdf |
| Summary: | Background: Accurate diagnosis of vesiculobullous lesions
of skin requires evaluation of clinical, histopathologic and
immunofluorescence findings.
Methods: A cross-sectional study of 68 patients to evaluate the
clinical, histopathological and direct immunofluorescence (DIF)
features in the diagnosis of cutaneous vesiculobullous disorders.
The patients with vesiculobullous lesions were subjected to
clinical examination regarding socio-demographic and clinical
data. Two biopsy specimens were taken, one from intact vesicle
for histopathological study and another from perilesional normal
looking skin or oral mucosa for DIF.
Results: Vesiculobullous lesions constituted 22.08% of total
number of skin biopsies. The most common clinical diagnosis
was pemphigus vulgaris (PV) in 36 cases, followed by bullous
pemphigoid (BP) in 8 cases, pemphigus foliaceous (PF) in 6
cases, and dermatitis herpetiformis (DH) in 4 cases. Characteristic
histopathological features were present in 26 cases of PV, 9
cases of BP and 4 cases of PF, and 17.7% showed non- specific
changes. DIF was positive in 24 cases of PV, 9 cases of BP and
3 cases of PF, and negative in 34.92% of cases.
Conclusion: Clinical, histopathological and DIF features together
or in combination help in the final diagnosis of vesiculobullous
disorders. Individually, none of these methods are diagnostic in
each and every case. |
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| ISSN: | 2249-782X 0973-709X |