Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment
Summary: Feeding rodents a high-fat diet (HFD) disrupts normal behavioral rhythms, particularly meal timing. Within the brain, mistimed feeding shifts molecular rhythms in the hippocampus and impairs memory. We hypothesize that altered meal timing induced by an HFD leads to cognitive impairment and...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221005009 |
| _version_ | 1818441038344224768 |
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| author | Jennifer A. Davis Jodi R. Paul Stefani D. Yates Elam J. Cutts Lori L. McMahon Jennifer S. Pollock David M. Pollock Shannon M. Bailey Karen L. Gamble |
| author_facet | Jennifer A. Davis Jodi R. Paul Stefani D. Yates Elam J. Cutts Lori L. McMahon Jennifer S. Pollock David M. Pollock Shannon M. Bailey Karen L. Gamble |
| author_sort | Jennifer A. Davis |
| collection | DOAJ |
| description | Summary: Feeding rodents a high-fat diet (HFD) disrupts normal behavioral rhythms, particularly meal timing. Within the brain, mistimed feeding shifts molecular rhythms in the hippocampus and impairs memory. We hypothesize that altered meal timing induced by an HFD leads to cognitive impairment and that restricting HFD access to the “active period” (i.e., night) rescues the normal hippocampal function. In male mice, ad-lib access to an HFD for 20 weeks increased body weight and fat mass, increased daytime meal consumption, reduced hippocampal long-term potentiation (LTP), and eliminated day/night differences in spatial working memory. Importantly, two weeks of time-restricted feeding (TRF) at the end of the chronic HFD protocol rescued spatial working memory and restored LTP magnitude, even though there was no change in body composition and total daily caloric intake. These findings suggest that short-term TRF is an effective mechanism for rescuing HFD-induced impaired cognition and hippocampal function. |
| first_indexed | 2024-12-14T18:21:54Z |
| format | Article |
| id | doaj.art-c9fca11a060d42c6834e34165e110ba1 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-14T18:21:54Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-c9fca11a060d42c6834e34165e110ba12022-12-21T22:52:02ZengElsevieriScience2589-00422021-06-01246102532Time-restricted feeding rescues high-fat-diet-induced hippocampal impairmentJennifer A. Davis0Jodi R. Paul1Stefani D. Yates2Elam J. Cutts3Lori L. McMahon4Jennifer S. Pollock5David M. Pollock6Shannon M. Bailey7Karen L. Gamble8Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Avenue S., Birmingham, AL 35294, USADepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Avenue S., Birmingham, AL 35294, USADepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Avenue S., Birmingham, AL 35294, USADepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Avenue S., Birmingham, AL 35294, USASchool of Medicine, Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USASchool of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USASchool of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USASchool of Medicine, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Avenue S., Birmingham, AL 35294, USA; Corresponding authorSummary: Feeding rodents a high-fat diet (HFD) disrupts normal behavioral rhythms, particularly meal timing. Within the brain, mistimed feeding shifts molecular rhythms in the hippocampus and impairs memory. We hypothesize that altered meal timing induced by an HFD leads to cognitive impairment and that restricting HFD access to the “active period” (i.e., night) rescues the normal hippocampal function. In male mice, ad-lib access to an HFD for 20 weeks increased body weight and fat mass, increased daytime meal consumption, reduced hippocampal long-term potentiation (LTP), and eliminated day/night differences in spatial working memory. Importantly, two weeks of time-restricted feeding (TRF) at the end of the chronic HFD protocol rescued spatial working memory and restored LTP magnitude, even though there was no change in body composition and total daily caloric intake. These findings suggest that short-term TRF is an effective mechanism for rescuing HFD-induced impaired cognition and hippocampal function.http://www.sciencedirect.com/science/article/pii/S2589004221005009Biological SciencesNeuroscienceCognitive Neuroscience |
| spellingShingle | Jennifer A. Davis Jodi R. Paul Stefani D. Yates Elam J. Cutts Lori L. McMahon Jennifer S. Pollock David M. Pollock Shannon M. Bailey Karen L. Gamble Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment iScience Biological Sciences Neuroscience Cognitive Neuroscience |
| title | Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment |
| title_full | Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment |
| title_fullStr | Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment |
| title_full_unstemmed | Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment |
| title_short | Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment |
| title_sort | time restricted feeding rescues high fat diet induced hippocampal impairment |
| topic | Biological Sciences Neuroscience Cognitive Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221005009 |
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