TFG: a novel regulator of ULK1-dependent autophagy
TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated prote...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.1945895 |
| _version_ | 1797677106462720000 |
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| author | Francesco Cecconi Francesca Nazio |
| author_facet | Francesco Cecconi Francesca Nazio |
| author_sort | Francesco Cecconi |
| collection | DOAJ |
| description | TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases. |
| first_indexed | 2024-03-11T22:40:12Z |
| format | Article |
| id | doaj.art-c9fd5093aee64032a0a57046d31f3127 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:12Z |
| publishDate | 2021-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-c9fd5093aee64032a0a57046d31f31272023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-07-018410.1080/23723556.2021.19458951945895TFG: a novel regulator of ULK1-dependent autophagyFrancesco Cecconi0Francesca Nazio1Bambino Gesù Children’s Hospital, IRCCSBambino Gesù Children’s Hospital, IRCCSTRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.http://dx.doi.org/10.1080/23723556.2021.1945895ulk1ergictfgomegasomeneurological disorders |
| spellingShingle | Francesco Cecconi Francesca Nazio TFG: a novel regulator of ULK1-dependent autophagy Molecular & Cellular Oncology ulk1 ergic tfg omegasome neurological disorders |
| title | TFG: a novel regulator of ULK1-dependent autophagy |
| title_full | TFG: a novel regulator of ULK1-dependent autophagy |
| title_fullStr | TFG: a novel regulator of ULK1-dependent autophagy |
| title_full_unstemmed | TFG: a novel regulator of ULK1-dependent autophagy |
| title_short | TFG: a novel regulator of ULK1-dependent autophagy |
| title_sort | tfg a novel regulator of ulk1 dependent autophagy |
| topic | ulk1 ergic tfg omegasome neurological disorders |
| url | http://dx.doi.org/10.1080/23723556.2021.1945895 |
| work_keys_str_mv | AT francescocecconi tfganovelregulatorofulk1dependentautophagy AT francescanazio tfganovelregulatorofulk1dependentautophagy |