Glyceric Prodrug of Ursodeoxycholic Acid (UDCA): Novozym 435-Catalyzed Synthesis of UDCA-Monoglyceride

Glyceric Prodrug of Ursodeoxycholic Acid (UDCA): Novozym 435-Catalyzed Synthesis of UDCA-Monoglyceride

Bile acids (BAs) are a family of steroids synthesized from cholesterol in the liver. Among bile acids, ursodeoxycholic acid (UDCA) is the drug of choice for treating primary biliary cirrhosis and dissolving cholesterol gallstones. The clinical effectiveness of UDCA includes its choleretic activity,...

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Bibliographic Details
Main Authors: Federico Zappaterra, Stefania Costa, Daniela Summa, Bruno Semeraro, Virginia Cristofori, Claudio Trapella, Elena Tamburini
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
ursodeoxycholic acid
monoglyceride
esterification
CALB
prodrug
Online Access:https://www.mdpi.com/1420-3049/26/19/5966

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