Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis

Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis

Cholestasis is common in multiple clinical circumstances. The NOD-like receptor protein 3 (NLRP3) inflammasome pathway has been demonstrated to play an important role in liver injury and fibrosis induced by cholestasis. We previously proved that MCC950, a selective NLRP3 inhibitor, alleviates liver...

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Bibliographic Details
Main Authors: Xiaopeng Wang, Guiyang Wang, Junwen Qu, Zhiqing Yuan, Ruogu Pan, Kewei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
cholestasis
fibrogenesis
calcipotriol
NLRP3 inflammasome
VDR
YAP1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00200/full

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