SLC19A1 and Thymidylate Synthase Polymorphisms Do not Predict Survival Outcome in Non-Small-Cell Lung Cancer Treated with Pemetrexed-Cisplatin Chemotherapy Regimen

SLC19A1 and Thymidylate Synthase Polymorphisms Do not Predict Survival Outcome in Non-Small-Cell Lung Cancer Treated with Pemetrexed-Cisplatin Chemotherapy Regimen

Background: Lung cancer is the leading cause of cancer deaths worldwide. Pharmacogenomics plays an important role in tailoring cancer patients’ treatment. Pemetrexed is widely used in first- and second-line chemotherapy of non-small cell lung cancer (NSCLC); however, there is no available predictive...

Full description

Bibliographic Details
Main Authors:	Mohammad Hadi Abbasian, Nafiseh Ansarinejad, Tayeb Ramim, Farshid Fardad, Bahareh Abbasi
Format:	Article
Language:	English
Published:	Shiraz University of Medical Sciences 2023-01-01
Series:	Middle East Journal of Cancer
Subjects:	non-small cell lung cancer thymidylate synthase slc19a pemetrexed polymorphism
Online Access:	https://mejc.sums.ac.ir/article_48279_6906424d8d389efe87089f7d09f4c56e.pdf

Similar Items

Thymidylate synthase inhibitors for thoracic tumors
by: Peters Godefridus J., et al.
Published: (2013-06-01)

Activity of pemetrexed in recurrent, metastatic sacral chordoma: A case report
by: Dominique G. Celestino, et al.
Published: (2025-03-01)

Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC
by: Wang Xia, et al.
Published: (2013-01-01)

Effect of PD-L1 expression on the efficacy of pemetrexed-based chemotherapy in patients with advanced lung adenocarcinoma and its mechanism
by: SHI Maolin , BAI Yudi , WANG Chao , LI Siqi , ZHOU Daijun , PENG Jingjing , SUN Feifan , LI Dong , ZHANG Tao
Published: (2021-04-01)

Relationship between the Expression of the Thymidylate Synthase and the Prognosis of Gastric Cancer Patients Treated with Combinational Chemotherapy Regimen Including Fluorouracil, Docetaxel and Cisplatin
by: Mozaffar Aznab, et al.
Published: (2020-07-01)

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities
by: Piotr Maj, et al.
Published: (2020-06-01)

Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies
by: Mohammad Mahboob Alam, et al.
Published: (2020-11-01)

Mechanistic and structural basis for inhibition of thymidylate synthase ThyX
by: Tamara Basta, et al.
Published: (2012-01-01)

Dynamic allostery in substrate binding by human thymidylate synthase
by: Jeffrey P Bonin, et al.
Published: (2022-10-01)

Regulation of 5‐fluorodeoxyuridine monophosphate‐thymidylate synthase ternary complex levels by autophagy confers resistance to 5‐fluorouracil
by: Nana Nishizawa, et al.
Published: (2023-01-01)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
by: Elżbieta Jagielska, et al.
Published: (2014-04-01)

Development and validation a radiomics nomogram for predicting thymidylate synthase status in hepatocellular carcinoma based on Gd-DTPA contrast enhanced MRI
by: Zongren Ding, et al.
Published: (2023-10-01)

Crystal structures of thymidylate synthase from nematodes, Trichinella spiralis and Caenorhabditis elegans, as a potential template for species-specific drug design
by: Dowierciał Anna, et al.
Published: (2013-06-01)

Visfatin and Resveratrol Differentially Regulate the Expression of Thymidylate Synthase to Control the Sensitivity of Human Colorectal Cancer Cells to Capecitabine Cytotoxicity
by: Kuen-Lin Wu, et al.
Published: (2021-12-01)

Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells
by: Changwon Yang, et al.
Published: (2021-11-01)

Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones
by: Stéphane Skouloubris, et al.
Published: (2015-01-01)

Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer
by: Changwon Yang, et al.
Published: (2022-10-01)

Molecular Characterization of Dihydrofolate Reductase-Thymidylate Synthase Gene Concerning Antifulate Resistance of Plasmodium vivax
by: K Sharifi, et al.
Published: (2009-12-01)

Molecular Characterization of Dihydrofolate Reductase-Thymidylate Synthase Gene Concerning Antifulate Resistance of Plasmodium vivax
by: N Hosseinzadeh, et al.
Published: (2009-12-01)

Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy
by: Nair Hariprasad Haritha, et al.
Published: (2021-07-01)

Influence of thymidylate synthase expression on survival in patients with colorectal cancer
by: Kinjal K Gajjar, et al.
Published: (2017-01-01)

Allelic polymorphisms of thymidylate synthase gene and their haplotypes as predictors of the therapeutic response to methotrexate in patients with rheumatoid arthritis
by: I. V. Devald, et al.
Published: (2019-05-01)

The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells
by: Fakhraddin Naghibalhossaini, et al.
Published: (2018-01-01)

Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate
by: Dowierciał Anna, et al.
Published: (2013-06-01)

Corrigendum: Targeting thymidylate synthase enhances the chemosensitivity of triple-negative breast cancer towards 5-FU-based combinatorial therapy
by: Nair Hariprasad Haritha, et al.
Published: (2023-12-01)

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation
by: Gaetano Marverti, et al.
Published: (2024-11-01)

Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase
by: Andrew L. Lee, et al.
Published: (2018-05-01)

A low-dose pemetrexed-cisplatin combination regimen induces significant nephrotoxicity in mice
by: Samson A. Iwhiwhu, et al.
Published: (2024-10-01)

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity
by: Godefridus J. Peters, et al.
Published: (2024-08-01)

Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth
by: Salvatore Pacifico, et al.
Published: (2019-09-01)

3’UTR polymorphism of Thymidylate Synthase gene increased the risk of persistence of pre-neoplastic cervical lesions
by: Nayara Nascimento Toledo Silva, et al.
Published: (2020-04-01)

Design, synthesis and in vitro antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors
by: Zohor Mohammad Mahdi Alzhrani, et al.
Published: (2020-01-01)

<i>Coptidis Rhizoma</i> Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase
by: Yong-Hwi Kang, et al.
Published: (2021-03-01)

A possible link to uracil DNA glycosylase in the synergistic action of HDAC inhibitors and thymidylate synthase inhibitors
by: Meredith S. Showler, et al.
Published: (2020-10-01)

Computational Identification of Druggable Bioactive Compounds from <i>Catharanthus roseus</i> and <i>Avicennia marina</i> against Colorectal Cancer by Targeting Thymidylate Synthase
by: Md Rashedul Islam, et al.
Published: (2022-03-01)

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
by: Luca Costantino, et al.
Published: (2022-12-01)

A phase I open-label, dose-escalation study of NUC-3373, a targeted thymidylate synthase inhibitor, in patients with advanced cancer (NuTide:301)
by: Pavlina Spiliopoulou, et al.
Published: (2024-04-01)

Association of expression and genotypes of thymidylate synthase in non-small cell lung cancer patients with different clinicopathological characteristics
by: Chen Jin-Yin, et al.
Published: (2021-06-01)

Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi
by: Bárbara Velame Ferreira Teixeira, et al.
Published: (2019-01-01)

Uncommon and parallel developmental patterns of thymidylate synthase expression and localization in Trichinella spiralis and Caenorhabditis elegans
by: Dąbrowska Magdalena, et al.
Published: (2013-06-01)