14-3-3 proteins regulate cullin 7-mediated Eag1 degradation

14-3-3 proteins regulate cullin 7-mediated Eag1 degradation

Abstract Background Mutations in the human gene encoding the neuron-specific Eag1 (KV10.1; KCNH1) potassium channel are linked to congenital neurodevelopmental diseases. Disease-causing mutant Eag1 channels manifest aberrant gating function and defective protein homeostasis. Both the E3 ubiquitin li...

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Main Authors: Chang-Heng Hsieh, Chia-Cheng Chou, Ya-Ching Fang, Po-Hao Hsu, Yi-Hung Chiu, Chi-Sheng Yang, Guey-Mei Jow, Chih-Yung Tang, Chung-Jiuan Jeng
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Cell & Bioscience
Subjects:
Ubiquitin ligase
Protein stability
Potassium channel
Proteasomal degradation
Lysosomal degradation
Protein interaction
Online Access:https://doi.org/10.1186/s13578-023-00969-w

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