Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases
Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and infla...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1157547/full |
| _version_ | 1797859716017160192 |
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| author | Laura Räisänen Heli Viljakainen Heli Viljakainen Kaija-Leena Kolho Kaija-Leena Kolho |
| author_facet | Laura Räisänen Heli Viljakainen Heli Viljakainen Kaija-Leena Kolho Kaija-Leena Kolho |
| author_sort | Laura Räisänen |
| collection | DOAJ |
| description | Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well. |
| first_indexed | 2024-04-09T21:34:06Z |
| format | Article |
| id | doaj.art-ca0002da34d4411a812625e1b62b2f8f |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-09T21:34:06Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ca0002da34d4411a812625e1b62b2f8f2023-03-27T05:55:26ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-03-011110.3389/fped.2023.11575471157547Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseasesLaura Räisänen0Heli Viljakainen1Heli Viljakainen2Kaija-Leena Kolho3Kaija-Leena Kolho4Department of Pediatrics, Tampere University Hospital, Tampere, FinlandPublic Health Research Program, Folkhälsan Research Center, Helsinki, FinlandChildren’s Hospital, University of Helsinki and HUS, Helsinki, FinlandChildren’s Hospital, University of Helsinki and HUS, Helsinki, FinlandFaculty of Medicine and Medical Technology, Tampere University, Tampere, FinlandProton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well.https://www.frontiersin.org/articles/10.3389/fped.2023.1157547/fullautoimmune thyroiditisinflammatory bowel diseasesjuvenile idiopathic arthritisomeprazoletype 1 diabetes mellitus |
| spellingShingle | Laura Räisänen Heli Viljakainen Heli Viljakainen Kaija-Leena Kolho Kaija-Leena Kolho Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases Frontiers in Pediatrics autoimmune thyroiditis inflammatory bowel diseases juvenile idiopathic arthritis omeprazole type 1 diabetes mellitus |
| title | Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases |
| title_full | Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases |
| title_fullStr | Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases |
| title_full_unstemmed | Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases |
| title_short | Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases |
| title_sort | exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases |
| topic | autoimmune thyroiditis inflammatory bowel diseases juvenile idiopathic arthritis omeprazole type 1 diabetes mellitus |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1157547/full |
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