Combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule-1 and tumor necrosis factor-α in hypertensive patients with prediabetes
Amlodipine and atorvastatin combination reduces levels of ICAM-1 and TNF-α in hypertensive prediabetesAbstractObjective: To assess the effect of amlodipine and atorvastatin on intercellular adhesion molecule (ICAM)-1 and tumor necrosis factor (TNF)-α expression, as endothelial function and inflamma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00206/full |
| _version_ | 1818984611716268032 |
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| author | Zhouqing Huang Chen Chen Sheng Li Fanqi Kong Peiren Shan Weijian Huang |
| author_facet | Zhouqing Huang Chen Chen Sheng Li Fanqi Kong Peiren Shan Weijian Huang |
| author_sort | Zhouqing Huang |
| collection | DOAJ |
| description | Amlodipine and atorvastatin combination reduces levels of ICAM-1 and TNF-α in hypertensive prediabetesAbstractObjective: To assess the effect of amlodipine and atorvastatin on intercellular adhesion molecule (ICAM)-1 and tumor necrosis factor (TNF)-α expression, as endothelial function and inflammation indicators, respectively, in hypertensive patients with and without prediabetes.Methods: Forty-five consecutive patients with hypertension, diagnosed according to JNC7, were divided into two groups based on the presence (HD group, n=23) or absence (H group, n=22) of prediabetes, diagnosed according to 2010 ADA criteria, including impaired glucose tolerance and fasting glucose. All patients simultaneously underwent 12-week treatment with daily single-pill amlodipine besylate/atorvastatin calcium combination (5/10mg; Hisun-Pfizer Pharmaceuticals Co. Ltd). Serum isolated before and after treatment from overnight fasting blood samples was analyzed by ELISA.Results: In the HD and H groups after vs. before 12-week amlodipine/atorvastatin treatment, there were significantly (all P <.01) lower levels of ICAM-1 (3.06 ± 0.34 vs. 4.07 ± 0.70 pg/ml; 3.26 ± 0.32 vs. 3.81 ± 0.60 pg/ml, respectively) and TNF-α (78.71 ± 9.19 vs. 110.94 ± 10.71 pg/ml; 80.95 ± 9.33 vs. 101.79 ±11.72 pg/ml, respectively), with more pronounced reductions in HD vs. H group (ICAM-1Δ: 1.01 ± 0.80 vs. 0.55 ± 0.64 pg/ml, respectively, P = 0.037; TNF-αΔ: 32.23 ± 14.33 vs. 20.84 ± 14.89 pg/ml, respectively, P= 0.011), independently from blood pressure and cholesterol level reduction.Conclusions: Amlodipine/atorvastatin improved endothelial function and inflammation, as reflected by lower circulating levels of ICAM-1 and TNF-α, more prominently in hypertensives with than without prediabetes. Starting statin treatment before overt diabetes in hypertensives thus might improve cardiovascular outcomes.Keywords: Amlodipine and atorvastatin calcium; prediabetes; hypertension; inflammation; endothelial dysfunction; intercellular adhesion molecule-1; tumor necrosis factor-α |
| first_indexed | 2024-12-20T18:21:46Z |
| format | Article |
| id | doaj.art-ca00f00573f149ca9ea469118d9daac3 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-20T18:21:46Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ca00f00573f149ca9ea469118d9daac32022-12-21T19:30:15ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-08-01810.3389/fnagi.2016.00206186611Combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule-1 and tumor necrosis factor-α in hypertensive patients with prediabetesZhouqing Huang0Chen Chen1Sheng Li2Fanqi Kong3Peiren Shan4Weijian Huang5the First Affiliated Hospital of WenZhou Medical Universitythe First Affiliated Hospital of WenZhou Medical Universitythe First Affiliated Hospital of WenZhou Medical Universitythe First Affiliated Hospital of WenZhou Medical Universitythe First Affiliated Hospital of WenZhou Medical Universitythe First Affiliated Hospital of WenZhou Medical UniversityAmlodipine and atorvastatin combination reduces levels of ICAM-1 and TNF-α in hypertensive prediabetesAbstractObjective: To assess the effect of amlodipine and atorvastatin on intercellular adhesion molecule (ICAM)-1 and tumor necrosis factor (TNF)-α expression, as endothelial function and inflammation indicators, respectively, in hypertensive patients with and without prediabetes.Methods: Forty-five consecutive patients with hypertension, diagnosed according to JNC7, were divided into two groups based on the presence (HD group, n=23) or absence (H group, n=22) of prediabetes, diagnosed according to 2010 ADA criteria, including impaired glucose tolerance and fasting glucose. All patients simultaneously underwent 12-week treatment with daily single-pill amlodipine besylate/atorvastatin calcium combination (5/10mg; Hisun-Pfizer Pharmaceuticals Co. Ltd). Serum isolated before and after treatment from overnight fasting blood samples was analyzed by ELISA.Results: In the HD and H groups after vs. before 12-week amlodipine/atorvastatin treatment, there were significantly (all P <.01) lower levels of ICAM-1 (3.06 ± 0.34 vs. 4.07 ± 0.70 pg/ml; 3.26 ± 0.32 vs. 3.81 ± 0.60 pg/ml, respectively) and TNF-α (78.71 ± 9.19 vs. 110.94 ± 10.71 pg/ml; 80.95 ± 9.33 vs. 101.79 ±11.72 pg/ml, respectively), with more pronounced reductions in HD vs. H group (ICAM-1Δ: 1.01 ± 0.80 vs. 0.55 ± 0.64 pg/ml, respectively, P = 0.037; TNF-αΔ: 32.23 ± 14.33 vs. 20.84 ± 14.89 pg/ml, respectively, P= 0.011), independently from blood pressure and cholesterol level reduction.Conclusions: Amlodipine/atorvastatin improved endothelial function and inflammation, as reflected by lower circulating levels of ICAM-1 and TNF-α, more prominently in hypertensives with than without prediabetes. Starting statin treatment before overt diabetes in hypertensives thus might improve cardiovascular outcomes.Keywords: Amlodipine and atorvastatin calcium; prediabetes; hypertension; inflammation; endothelial dysfunction; intercellular adhesion molecule-1; tumor necrosis factor-αhttp://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00206/fullHypertensionInflammationIntercellular Adhesion Molecule-1endothelial dysfunctionprediabetestumor necrosis factor-α |
| spellingShingle | Zhouqing Huang Chen Chen Sheng Li Fanqi Kong Peiren Shan Weijian Huang Combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule-1 and tumor necrosis factor-α in hypertensive patients with prediabetes Frontiers in Aging Neuroscience Hypertension Inflammation Intercellular Adhesion Molecule-1 endothelial dysfunction prediabetes tumor necrosis factor-α |
| title | Combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule-1 and tumor necrosis factor-α in hypertensive patients with prediabetes |
| title_full | Combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule-1 and tumor necrosis factor-α in hypertensive patients with prediabetes |
| title_fullStr | Combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule-1 and tumor necrosis factor-α in hypertensive patients with prediabetes |
| title_full_unstemmed | Combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule-1 and tumor necrosis factor-α in hypertensive patients with prediabetes |
| title_short | Combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule-1 and tumor necrosis factor-α in hypertensive patients with prediabetes |
| title_sort | combined treatment with amlodipine and atorvastatin calcium reduces circulating levels of intercellular adhesion molecule 1 and tumor necrosis factor α in hypertensive patients with prediabetes |
| topic | Hypertension Inflammation Intercellular Adhesion Molecule-1 endothelial dysfunction prediabetes tumor necrosis factor-α |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00206/full |
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