Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways
Purpose: The mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) pathways have emerged as essential intracellular signaling pathways in eukaryotic cells, particularly as regulators of cardiac hypertrophy. Previous studies indicated that arctiin, an active ingredient of biennial drie...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-11-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861317301032 |
| _version_ | 1819171520735346688 |
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| author | Jing Li Yu-Pei Yuan Si-Chi Xu Ning Zhang Chun-Ru Xu Chun-Xia Wan Jie Ren Xiao-Feng Zeng Qi-Zhu Tang |
| author_facet | Jing Li Yu-Pei Yuan Si-Chi Xu Ning Zhang Chun-Ru Xu Chun-Xia Wan Jie Ren Xiao-Feng Zeng Qi-Zhu Tang |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Purpose: The mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) pathways have emerged as essential intracellular signaling pathways in eukaryotic cells, particularly as regulators of cardiac hypertrophy. Previous studies indicated that arctiin, an active ingredient of biennial dried ripe burdock, could exhibit potent anti-inflammatory and anti-allergic activities via down-regulating the activation of MAPKs and AKT pathways. However, little is known about its effects on cardiac hypertrophy. Therefore, the present study aimed to explore whether arctiin could attenuate cardiac hypertrophy.
General methods: Arctiin (80 mg/kg) was administered by oral gavage once daily for 3 weeks from 1 week after surgery. Then, the mice were subjected to either chronic pressure overload generated by aortic banding (AB) or sham surgery (control group). Cardiac function was assessed by echocardiography.
Findings: The results indicated that arctiin attenuated cardiac hypertrophy induced by AB, and suppressed cardiac fibrosis and accumulation of collagen in vivo. Arctiin also inhibit the activation of MAPKs and AKT occurs in response to hypertrophic stimuli. Arctiin attenuated phenylephrine-induced hypertrophy of myocytes in vitro.
Conclusions: In conclusion, arctiin can improve cardiac function and prevent the development of cardiac hypertrophy by blocking the MAPKs and AKT signaling pathways. |
| first_indexed | 2024-12-22T19:52:36Z |
| format | Article |
| id | doaj.art-ca01ee5ff3ce478aafd893089ae83a8c |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-22T19:52:36Z |
| publishDate | 2017-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-ca01ee5ff3ce478aafd893089ae83a8c2022-12-21T18:14:31ZengElsevierJournal of Pharmacological Sciences1347-86132017-11-0113539710410.1016/j.jphs.2017.05.012Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathwaysJing Li0Yu-Pei Yuan1Si-Chi Xu2Ning Zhang3Chun-Ru Xu4Chun-Xia Wan5Jie Ren6Xiao-Feng Zeng7Qi-Zhu Tang8Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaPurpose: The mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) pathways have emerged as essential intracellular signaling pathways in eukaryotic cells, particularly as regulators of cardiac hypertrophy. Previous studies indicated that arctiin, an active ingredient of biennial dried ripe burdock, could exhibit potent anti-inflammatory and anti-allergic activities via down-regulating the activation of MAPKs and AKT pathways. However, little is known about its effects on cardiac hypertrophy. Therefore, the present study aimed to explore whether arctiin could attenuate cardiac hypertrophy. General methods: Arctiin (80 mg/kg) was administered by oral gavage once daily for 3 weeks from 1 week after surgery. Then, the mice were subjected to either chronic pressure overload generated by aortic banding (AB) or sham surgery (control group). Cardiac function was assessed by echocardiography. Findings: The results indicated that arctiin attenuated cardiac hypertrophy induced by AB, and suppressed cardiac fibrosis and accumulation of collagen in vivo. Arctiin also inhibit the activation of MAPKs and AKT occurs in response to hypertrophic stimuli. Arctiin attenuated phenylephrine-induced hypertrophy of myocytes in vitro. Conclusions: In conclusion, arctiin can improve cardiac function and prevent the development of cardiac hypertrophy by blocking the MAPKs and AKT signaling pathways.http://www.sciencedirect.com/science/article/pii/S1347861317301032ArctiinCardiac hypertrophyCardiac fibrosisMAPKsAKT |
| spellingShingle | Jing Li Yu-Pei Yuan Si-Chi Xu Ning Zhang Chun-Ru Xu Chun-Xia Wan Jie Ren Xiao-Feng Zeng Qi-Zhu Tang Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways Journal of Pharmacological Sciences Arctiin Cardiac hypertrophy Cardiac fibrosis MAPKs AKT |
| title | Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways |
| title_full | Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways |
| title_fullStr | Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways |
| title_full_unstemmed | Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways |
| title_short | Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways |
| title_sort | arctiin protects against cardiac hypertrophy through inhibiting mapks and akt signaling pathways |
| topic | Arctiin Cardiac hypertrophy Cardiac fibrosis MAPKs AKT |
| url | http://www.sciencedirect.com/science/article/pii/S1347861317301032 |
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