Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans.
Cerebrospinal fluid (CSF) flow maintains healthy brain homeostasis, facilitating solute transport and the exchange of brain waste products. CSF flow is thus important for brain health, but the mechanisms that control its large-scale movement through the ventricles are not well understood. While it i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-03-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002035 |
| _version_ | 1797837264536993792 |
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| author | Stephanie D Williams Beverly Setzer Nina E Fultz Zenia Valdiviezo Nicole Tacugue Zachary Diamandis Laura D Lewis |
| author_facet | Stephanie D Williams Beverly Setzer Nina E Fultz Zenia Valdiviezo Nicole Tacugue Zachary Diamandis Laura D Lewis |
| author_sort | Stephanie D Williams |
| collection | DOAJ |
| description | Cerebrospinal fluid (CSF) flow maintains healthy brain homeostasis, facilitating solute transport and the exchange of brain waste products. CSF flow is thus important for brain health, but the mechanisms that control its large-scale movement through the ventricles are not well understood. While it is well established that CSF flow is modulated by respiratory and cardiovascular dynamics, recent work has also demonstrated that neural activity is coupled to large waves of CSF flow in the ventricles during sleep. To test whether the temporal coupling between neural activity and CSF flow is in part due to a causal relationship, we investigated whether CSF flow could be induced by driving neural activity with intense visual stimulation. We manipulated neural activity with a flickering checkerboard visual stimulus and found that we could drive macroscopic CSF flow in the human brain. The timing and amplitude of CSF flow was matched to the visually evoked hemodynamic responses, suggesting neural activity can modulate CSF flow via neurovascular coupling. These results demonstrate that neural activity can contribute to driving CSF flow in the human brain and that the temporal dynamics of neurovascular coupling can explain this effect. |
| first_indexed | 2024-04-09T15:22:59Z |
| format | Article |
| id | doaj.art-ca0287742cef4055a6946927df9645f5 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-04-09T15:22:59Z |
| publishDate | 2023-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-ca0287742cef4055a6946927df9645f52023-04-29T05:30:52ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-03-01213e300203510.1371/journal.pbio.3002035Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans.Stephanie D WilliamsBeverly SetzerNina E FultzZenia ValdiviezoNicole TacugueZachary DiamandisLaura D LewisCerebrospinal fluid (CSF) flow maintains healthy brain homeostasis, facilitating solute transport and the exchange of brain waste products. CSF flow is thus important for brain health, but the mechanisms that control its large-scale movement through the ventricles are not well understood. While it is well established that CSF flow is modulated by respiratory and cardiovascular dynamics, recent work has also demonstrated that neural activity is coupled to large waves of CSF flow in the ventricles during sleep. To test whether the temporal coupling between neural activity and CSF flow is in part due to a causal relationship, we investigated whether CSF flow could be induced by driving neural activity with intense visual stimulation. We manipulated neural activity with a flickering checkerboard visual stimulus and found that we could drive macroscopic CSF flow in the human brain. The timing and amplitude of CSF flow was matched to the visually evoked hemodynamic responses, suggesting neural activity can modulate CSF flow via neurovascular coupling. These results demonstrate that neural activity can contribute to driving CSF flow in the human brain and that the temporal dynamics of neurovascular coupling can explain this effect.https://doi.org/10.1371/journal.pbio.3002035 |
| spellingShingle | Stephanie D Williams Beverly Setzer Nina E Fultz Zenia Valdiviezo Nicole Tacugue Zachary Diamandis Laura D Lewis Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans. PLoS Biology |
| title | Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans. |
| title_full | Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans. |
| title_fullStr | Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans. |
| title_full_unstemmed | Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans. |
| title_short | Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans. |
| title_sort | neural activity induced by sensory stimulation can drive large scale cerebrospinal fluid flow during wakefulness in humans |
| url | https://doi.org/10.1371/journal.pbio.3002035 |
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