Human papillomavirus integration transforms chromatin to drive oncogenesis
Abstract Background Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers. Frequent integration into the host genome occurs predominantly in tumorigenic types of HPV. We hypothesize that changes in chromatin state at the location of integration can resu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-06-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-023-02926-9 |