Acute interstitial nephritis in the south of Iran; an observational study
Background: Acute interstitial nephritis (AIN) is an emerging cause of acute kidney injury (AKI) during the recent years. Objectives: There is no data about prevalence, causes, clinical manifestation and outcomes of AIN in our region. Hence, in this study we aimed to find the prevalence of AIN and d...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2017-07-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-6-225.pdf |
| _version_ | 1797828002409611264 |
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| author | Zohre Khodamoradi Maryam Pakfetrat Simin Torabinezhad Mohammad Mahdi Sagheb |
| author_facet | Zohre Khodamoradi Maryam Pakfetrat Simin Torabinezhad Mohammad Mahdi Sagheb |
| author_sort | Zohre Khodamoradi |
| collection | DOAJ |
| description | Background: Acute interstitial nephritis (AIN) is an emerging cause of acute kidney injury (AKI) during the recent years. Objectives: There is no data about prevalence, causes, clinical manifestation and outcomes of AIN in our region. Hence, in this study we aimed to find the prevalence of AIN and describe the causes, clinical presentation, and the outcome of AIN in the native kidney biopsies. Patients and Methods: We reviewed 934 native kidney biopsies from 2006 to 2014 and collected the data of patients with the diagnosis of AIN including medical history, clinical findings, para-clinical data, pathologic findings, treatment and outcomes. Results: Prevalence of AIN in our center during 2006 to 2014 was 2.5% of all renal biopsies. The common cause of AIN in our study was drugs. Of those patients admitted to hospital due to AIN, 17 patients (70.8%) received corticosteroid, five of them (29.4%) received pulse of corticosteroid, and 12 patients (70.6%) received oral drug. Around, 54.2% of the patients had hemodialysis during admission. Eight patients had received both dialysis and corticosteroid. Two of them (8.3%) remained on dialysis and 8 (33.3%) developed chronic kidney disease, but 14 (58.3%) patients recovered. Conclusions: The prevalence of AIN in our study is comparable to other studies and we found the great impact of medications on development of AIN. |
| first_indexed | 2024-04-09T12:57:29Z |
| format | Article |
| id | doaj.art-ca04de165c984b0299a0c0352d05e2e1 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:29Z |
| publishDate | 2017-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-ca04de165c984b0299a0c0352d05e2e12023-05-13T11:31:23ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192017-07-016322523010.15171/jnp.2017.37jnp-20170517141650Acute interstitial nephritis in the south of Iran; an observational studyZohre Khodamoradi0Maryam Pakfetrat1Simin Torabinezhad2Mohammad Mahdi Sagheb3Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Nephrology, Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Nephrology, Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, IranBackground: Acute interstitial nephritis (AIN) is an emerging cause of acute kidney injury (AKI) during the recent years. Objectives: There is no data about prevalence, causes, clinical manifestation and outcomes of AIN in our region. Hence, in this study we aimed to find the prevalence of AIN and describe the causes, clinical presentation, and the outcome of AIN in the native kidney biopsies. Patients and Methods: We reviewed 934 native kidney biopsies from 2006 to 2014 and collected the data of patients with the diagnosis of AIN including medical history, clinical findings, para-clinical data, pathologic findings, treatment and outcomes. Results: Prevalence of AIN in our center during 2006 to 2014 was 2.5% of all renal biopsies. The common cause of AIN in our study was drugs. Of those patients admitted to hospital due to AIN, 17 patients (70.8%) received corticosteroid, five of them (29.4%) received pulse of corticosteroid, and 12 patients (70.6%) received oral drug. Around, 54.2% of the patients had hemodialysis during admission. Eight patients had received both dialysis and corticosteroid. Two of them (8.3%) remained on dialysis and 8 (33.3%) developed chronic kidney disease, but 14 (58.3%) patients recovered. Conclusions: The prevalence of AIN in our study is comparable to other studies and we found the great impact of medications on development of AIN.https://nephropathol.com/PDF/jnp-6-225.pdfacute interstitial nephritissteroid treatmentkidney biopsyacute kidney injury |
| spellingShingle | Zohre Khodamoradi Maryam Pakfetrat Simin Torabinezhad Mohammad Mahdi Sagheb Acute interstitial nephritis in the south of Iran; an observational study Journal of Nephropathology acute interstitial nephritis steroid treatment kidney biopsy acute kidney injury |
| title | Acute interstitial nephritis in the south of Iran; an observational study |
| title_full | Acute interstitial nephritis in the south of Iran; an observational study |
| title_fullStr | Acute interstitial nephritis in the south of Iran; an observational study |
| title_full_unstemmed | Acute interstitial nephritis in the south of Iran; an observational study |
| title_short | Acute interstitial nephritis in the south of Iran; an observational study |
| title_sort | acute interstitial nephritis in the south of iran an observational study |
| topic | acute interstitial nephritis steroid treatment kidney biopsy acute kidney injury |
| url | https://nephropathol.com/PDF/jnp-6-225.pdf |
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