Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease
Abstract Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Chemistry Central Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13065-018-0497-z |
| _version_ | 1818365270410919936 |
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| author | Samina Khan Yusufzai Mohammad Shaheen Khan Othman Sulaiman Hasnah Osman Dalily Nabilah Lamjin |
| author_facet | Samina Khan Yusufzai Mohammad Shaheen Khan Othman Sulaiman Hasnah Osman Dalily Nabilah Lamjin |
| author_sort | Samina Khan Yusufzai |
| collection | DOAJ |
| description | Abstract Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin based conjugates have been described as potential AChE, BuChE, MAO and β-amyloid inhibitors. Therefore, the objective of this review is to focus on the construction of these pharmacologically important coumarin analogues with anti-Alzheimer’s activities, highlight their docking studies and structure–activity relationships based on their substitution pattern with respect to the selected positions on the chromen ring by emphasising on the research reports conducted in between year 1968 to 2017. |
| first_indexed | 2024-12-13T22:17:36Z |
| format | Article |
| id | doaj.art-ca072bd9cec047479d7ee4dacde32a3a |
| institution | Directory Open Access Journal |
| issn | 1752-153X |
| language | English |
| last_indexed | 2024-12-13T22:17:36Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Chemistry Central Journal |
| spelling | doaj.art-ca072bd9cec047479d7ee4dacde32a3a2022-12-21T23:29:28ZengBMCChemistry Central Journal1752-153X2018-12-0112115710.1186/s13065-018-0497-zMolecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s diseaseSamina Khan Yusufzai0Mohammad Shaheen Khan1Othman Sulaiman2Hasnah Osman3Dalily Nabilah Lamjin4School of Industrial Technology, Universiti Sains MalaysiaIndustrial Chemistry Programme, Faculty of Science and Natural Resources, Universiti Malaysia SabahSchool of Industrial Technology, Universiti Sains MalaysiaSchool of Chemical Sciences, Universiti Sains MalaysiaIndustrial Chemistry Programme, Faculty of Science and Natural Resources, Universiti Malaysia SabahAbstract Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin based conjugates have been described as potential AChE, BuChE, MAO and β-amyloid inhibitors. Therefore, the objective of this review is to focus on the construction of these pharmacologically important coumarin analogues with anti-Alzheimer’s activities, highlight their docking studies and structure–activity relationships based on their substitution pattern with respect to the selected positions on the chromen ring by emphasising on the research reports conducted in between year 1968 to 2017.http://link.springer.com/article/10.1186/s13065-018-0497-zCoumarinNeurodegenerative disorderAlzheimer’s diseaseAcetylcholinesteraseButyrylcholinesteraseMonoamine oxidase |
| spellingShingle | Samina Khan Yusufzai Mohammad Shaheen Khan Othman Sulaiman Hasnah Osman Dalily Nabilah Lamjin Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease Chemistry Central Journal Coumarin Neurodegenerative disorder Alzheimer’s disease Acetylcholinesterase Butyrylcholinesterase Monoamine oxidase |
| title | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease |
| title_full | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease |
| title_fullStr | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease |
| title_full_unstemmed | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease |
| title_short | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease |
| title_sort | molecular docking studies of coumarin hybrids as potential acetylcholinesterase butyrylcholinesterase monoamine oxidase a b and β amyloid inhibitors for alzheimer s disease |
| topic | Coumarin Neurodegenerative disorder Alzheimer’s disease Acetylcholinesterase Butyrylcholinesterase Monoamine oxidase |
| url | http://link.springer.com/article/10.1186/s13065-018-0497-z |
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