Use of the Codon Table to Quantify the Evolutionary Role of Random Mutations
The various biases affecting RNA mutations during evolution is the subject of intense research, leaving the extent of the role of random mutations undefined. To remedy this lacuna, using the codon table, the number of codons representing each amino acid was correlated with the amino acid frequencies...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Algorithms |
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| Online Access: | https://www.mdpi.com/1999-4893/14/9/270 |
| _version_ | 1797520555545460736 |
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| author | Mihaly Mezei |
| author_facet | Mihaly Mezei |
| author_sort | Mihaly Mezei |
| collection | DOAJ |
| description | The various biases affecting RNA mutations during evolution is the subject of intense research, leaving the extent of the role of random mutations undefined. To remedy this lacuna, using the codon table, the number of codons representing each amino acid was correlated with the amino acid frequencies in different branches of the evolutionary tree. The correlations were seen to increase as evolution progressed. Furthermore, the number of RNA mutations that resulted in a given amino acid mutation were found to be correlated with several widely used amino acid similarity tables (used in sequence alignments). These correlations were seen to increase when the observed codon usage was factored in. |
| first_indexed | 2024-03-10T07:58:28Z |
| format | Article |
| id | doaj.art-ca085c75aea44d06b1b879f0fab0e3fc |
| institution | Directory Open Access Journal |
| issn | 1999-4893 |
| language | English |
| last_indexed | 2024-03-10T07:58:28Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Algorithms |
| spelling | doaj.art-ca085c75aea44d06b1b879f0fab0e3fc2023-11-22T11:40:26ZengMDPI AGAlgorithms1999-48932021-09-0114927010.3390/a14090270Use of the Codon Table to Quantify the Evolutionary Role of Random MutationsMihaly Mezei0Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAThe various biases affecting RNA mutations during evolution is the subject of intense research, leaving the extent of the role of random mutations undefined. To remedy this lacuna, using the codon table, the number of codons representing each amino acid was correlated with the amino acid frequencies in different branches of the evolutionary tree. The correlations were seen to increase as evolution progressed. Furthermore, the number of RNA mutations that resulted in a given amino acid mutation were found to be correlated with several widely used amino acid similarity tables (used in sequence alignments). These correlations were seen to increase when the observed codon usage was factored in.https://www.mdpi.com/1999-4893/14/9/270codon tableamino acid propensitymutation probabilityamino-acid substitution matrix |
| spellingShingle | Mihaly Mezei Use of the Codon Table to Quantify the Evolutionary Role of Random Mutations Algorithms codon table amino acid propensity mutation probability amino-acid substitution matrix |
| title | Use of the Codon Table to Quantify the Evolutionary Role of Random Mutations |
| title_full | Use of the Codon Table to Quantify the Evolutionary Role of Random Mutations |
| title_fullStr | Use of the Codon Table to Quantify the Evolutionary Role of Random Mutations |
| title_full_unstemmed | Use of the Codon Table to Quantify the Evolutionary Role of Random Mutations |
| title_short | Use of the Codon Table to Quantify the Evolutionary Role of Random Mutations |
| title_sort | use of the codon table to quantify the evolutionary role of random mutations |
| topic | codon table amino acid propensity mutation probability amino-acid substitution matrix |
| url | https://www.mdpi.com/1999-4893/14/9/270 |
| work_keys_str_mv | AT mihalymezei useofthecodontabletoquantifytheevolutionaryroleofrandommutations |