Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, so...
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11465 |
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| author | Ewa Szczepanska-Sadowska Agnieszka Wsol Agnieszka Cudnoch-Jedrzejewska Tymoteusz Żera |
| author_facet | Ewa Szczepanska-Sadowska Agnieszka Wsol Agnieszka Cudnoch-Jedrzejewska Tymoteusz Żera |
| author_sort | Ewa Szczepanska-Sadowska |
| collection | DOAJ |
| description | The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases. |
| first_indexed | 2024-03-10T06:02:01Z |
| format | Article |
| id | doaj.art-ca08fa6e6f4040b1aabddb4b719c4eb9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:02:01Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ca08fa6e6f4040b1aabddb4b719c4eb92023-11-22T20:52:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211146510.3390/ijms222111465Complementary Role of Oxytocin and Vasopressin in Cardiovascular RegulationEwa Szczepanska-Sadowska0Agnieszka Wsol1Agnieszka Cudnoch-Jedrzejewska2Tymoteusz Żera3Laboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, PolandLaboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, PolandLaboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, PolandLaboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, PolandThe neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases.https://www.mdpi.com/1422-0067/22/21/11465oxytocinvasopressinhypertensionmyocardial infarctionstress |
| spellingShingle | Ewa Szczepanska-Sadowska Agnieszka Wsol Agnieszka Cudnoch-Jedrzejewska Tymoteusz Żera Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation International Journal of Molecular Sciences oxytocin vasopressin hypertension myocardial infarction stress |
| title | Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation |
| title_full | Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation |
| title_fullStr | Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation |
| title_full_unstemmed | Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation |
| title_short | Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation |
| title_sort | complementary role of oxytocin and vasopressin in cardiovascular regulation |
| topic | oxytocin vasopressin hypertension myocardial infarction stress |
| url | https://www.mdpi.com/1422-0067/22/21/11465 |
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