Histone variant H3.3 and its future prospects in cancer clinic
Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its canonical counterparts H3.1/3.2. Second, H3.3...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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Series: | Journal of Radiation and Cancer Research |
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Online Access: | http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=77;epage=81;aulast=Reddy |
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author | Divya Reddy Sanjay Gupta |
author_facet | Divya Reddy Sanjay Gupta |
author_sort | Divya Reddy |
collection | DOAJ |
description | Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its canonical counterparts H3.1/3.2. Second, H3.3 has been consistently associated with an active state of chromatin. Apart from this function research in the past few years has also revealed that H3.3 has a central role to play in maintaining the somatic cell identity, for efficient ultraviolet induce DNA damage repair and proper segregation of chromosomes during cell division. Further, the discovery of “driver mutations” on this variant has bought it to limelight in cancer biology to the extent that “oncohistone,” a new term has been coined for different mutants of H3.3. Here, we review the functional importance of H3.3 in the context of cancer. |
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format | Article |
id | doaj.art-ca091ff62fa246bc866c9cf30191cb5e |
institution | Directory Open Access Journal |
issn | 2588-9273 2468-9203 |
language | English |
last_indexed | 2024-12-10T23:24:22Z |
publishDate | 2017-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Journal of Radiation and Cancer Research |
spelling | doaj.art-ca091ff62fa246bc866c9cf30191cb5e2022-12-22T01:29:38ZengWolters Kluwer Medknow PublicationsJournal of Radiation and Cancer Research2588-92732468-92032017-01-0181778110.4103/jrcr.jrcr_4_17Histone variant H3.3 and its future prospects in cancer clinicDivya ReddySanjay GuptaHistone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its canonical counterparts H3.1/3.2. Second, H3.3 has been consistently associated with an active state of chromatin. Apart from this function research in the past few years has also revealed that H3.3 has a central role to play in maintaining the somatic cell identity, for efficient ultraviolet induce DNA damage repair and proper segregation of chromosomes during cell division. Further, the discovery of “driver mutations” on this variant has bought it to limelight in cancer biology to the extent that “oncohistone,” a new term has been coined for different mutants of H3.3. Here, we review the functional importance of H3.3 in the context of cancer.http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=77;epage=81;aulast=ReddyCancerDNA damageepigenomemutationoncohistone |
spellingShingle | Divya Reddy Sanjay Gupta Histone variant H3.3 and its future prospects in cancer clinic Journal of Radiation and Cancer Research Cancer DNA damage epigenome mutation oncohistone |
title | Histone variant H3.3 and its future prospects in cancer clinic |
title_full | Histone variant H3.3 and its future prospects in cancer clinic |
title_fullStr | Histone variant H3.3 and its future prospects in cancer clinic |
title_full_unstemmed | Histone variant H3.3 and its future prospects in cancer clinic |
title_short | Histone variant H3.3 and its future prospects in cancer clinic |
title_sort | histone variant h3 3 and its future prospects in cancer clinic |
topic | Cancer DNA damage epigenome mutation oncohistone |
url | http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=77;epage=81;aulast=Reddy |
work_keys_str_mv | AT divyareddy histonevarianth33anditsfutureprospectsincancerclinic AT sanjaygupta histonevarianth33anditsfutureprospectsincancerclinic |