Histone variant H3.3 and its future prospects in cancer clinic

Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its canonical counterparts H3.1/3.2. Second, H3.3...

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Main Authors: Divya Reddy, Sanjay Gupta
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Journal of Radiation and Cancer Research
Subjects:
Online Access:http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=77;epage=81;aulast=Reddy
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author Divya Reddy
Sanjay Gupta
author_facet Divya Reddy
Sanjay Gupta
author_sort Divya Reddy
collection DOAJ
description Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its canonical counterparts H3.1/3.2. Second, H3.3 has been consistently associated with an active state of chromatin. Apart from this function research in the past few years has also revealed that H3.3 has a central role to play in maintaining the somatic cell identity, for efficient ultraviolet induce DNA damage repair and proper segregation of chromosomes during cell division. Further, the discovery of “driver mutations” on this variant has bought it to limelight in cancer biology to the extent that “oncohistone,” a new term has been coined for different mutants of H3.3. Here, we review the functional importance of H3.3 in the context of cancer.
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spelling doaj.art-ca091ff62fa246bc866c9cf30191cb5e2022-12-22T01:29:38ZengWolters Kluwer Medknow PublicationsJournal of Radiation and Cancer Research2588-92732468-92032017-01-0181778110.4103/jrcr.jrcr_4_17Histone variant H3.3 and its future prospects in cancer clinicDivya ReddySanjay GuptaHistone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its canonical counterparts H3.1/3.2. Second, H3.3 has been consistently associated with an active state of chromatin. Apart from this function research in the past few years has also revealed that H3.3 has a central role to play in maintaining the somatic cell identity, for efficient ultraviolet induce DNA damage repair and proper segregation of chromosomes during cell division. Further, the discovery of “driver mutations” on this variant has bought it to limelight in cancer biology to the extent that “oncohistone,” a new term has been coined for different mutants of H3.3. Here, we review the functional importance of H3.3 in the context of cancer.http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=77;epage=81;aulast=ReddyCancerDNA damageepigenomemutationoncohistone
spellingShingle Divya Reddy
Sanjay Gupta
Histone variant H3.3 and its future prospects in cancer clinic
Journal of Radiation and Cancer Research
Cancer
DNA damage
epigenome
mutation
oncohistone
title Histone variant H3.3 and its future prospects in cancer clinic
title_full Histone variant H3.3 and its future prospects in cancer clinic
title_fullStr Histone variant H3.3 and its future prospects in cancer clinic
title_full_unstemmed Histone variant H3.3 and its future prospects in cancer clinic
title_short Histone variant H3.3 and its future prospects in cancer clinic
title_sort histone variant h3 3 and its future prospects in cancer clinic
topic Cancer
DNA damage
epigenome
mutation
oncohistone
url http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=77;epage=81;aulast=Reddy
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