Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly(phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness

Abstract Dry eye disease (DED) is associated with ocular hyperosmolarity and inflammation. The marketed topical eye drops for DED treatment often lack bioavailability and precorneal residence time. In this study, we investigated catechol-functionalized polyzwitterion p(MPC-co-DMA), composed of 2-met...

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Hlavní autoři: Hoang Linh Bui, Yun-Han Su, Chia-Jung Yang, Chun-Jen Huang, Jui-Yang Lai
Médium: Článek
Jazyk:English
Vydáno: BMC 2024-04-01
Edice:Journal of Nanobiotechnology
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On-line přístup:https://doi.org/10.1186/s12951-024-02448-x

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