Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly(phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness

Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly(phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness

Abstract Dry eye disease (DED) is associated with ocular hyperosmolarity and inflammation. The marketed topical eye drops for DED treatment often lack bioavailability and precorneal residence time. In this study, we investigated catechol-functionalized polyzwitterion p(MPC-co-DMA), composed of 2-met...

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Bibliographic Details
Main Authors: Hoang Linh Bui, Yun-Han Su, Chia-Jung Yang, Chun-Jen Huang, Jui-Yang Lai
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Nanobiotechnology
Subjects:
Multifunctional polyzwitterion
Catechol
Poly(phosphobetaine)
Biomaterial nanotherapeutics
Ocular dryness
Online Access:https://doi.org/10.1186/s12951-024-02448-x

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