A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells
Objective To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. Methods A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and dithiocarbamate scaffolds. The anticancer effects of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520928831 |
| _version_ | 1819259812022583296 |
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| author | Jie Chen Chun-Yan Kang Zhao-Xia Niu Hui-Cong Zhou Hong-Mei Yang |
| author_facet | Jie Chen Chun-Yan Kang Zhao-Xia Niu Hui-Cong Zhou Hong-Mei Yang |
| author_sort | Jie Chen |
| collection | DOAJ |
| description | Objective To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. Methods A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and dithiocarbamate scaffolds. The anticancer effects of different concentrations of the chalcone derivative were compared in esophageal cancer cells. Results This chalcone displayed strong inhibitory effects on esophageal cancer cell growth with an IC 50 of 1.06 μM in KYSE-4 cells. Analysis of the mechanism revealed that the derivative obviously inhibited KYSE-4 cell growth, migration, and invasion in a concentration-dependent manner. Furthermore, the compound regulated migration-related biomarkers (E-cadherin, N-cadherin, and Slug) and inhibited the Wnt/β-catenin pathway. According to western blotting, this chalcone suppressed the expression of proline-rich protein 11 (PRR11) in a concentration- and time-dependent manner. Conclusions This chalcone might be a leading candidate for suppressing the growth and metastasis of esophageal cancer by downregulating PRR11 expression and inhibiting Wnt/β-catenin signaling. |
| first_indexed | 2024-12-23T19:15:57Z |
| format | Article |
| id | doaj.art-ca0be7e2f2f24d608b82ac60abf3a428 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-23T19:15:57Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-ca0be7e2f2f24d608b82ac60abf3a4282022-12-21T17:34:19ZengSAGE PublishingJournal of International Medical Research1473-23002020-06-014810.1177/0300060520928831A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cellsJie ChenChun-Yan KangZhao-Xia NiuHui-Cong ZhouHong-Mei YangObjective To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. Methods A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and dithiocarbamate scaffolds. The anticancer effects of different concentrations of the chalcone derivative were compared in esophageal cancer cells. Results This chalcone displayed strong inhibitory effects on esophageal cancer cell growth with an IC 50 of 1.06 μM in KYSE-4 cells. Analysis of the mechanism revealed that the derivative obviously inhibited KYSE-4 cell growth, migration, and invasion in a concentration-dependent manner. Furthermore, the compound regulated migration-related biomarkers (E-cadherin, N-cadherin, and Slug) and inhibited the Wnt/β-catenin pathway. According to western blotting, this chalcone suppressed the expression of proline-rich protein 11 (PRR11) in a concentration- and time-dependent manner. Conclusions This chalcone might be a leading candidate for suppressing the growth and metastasis of esophageal cancer by downregulating PRR11 expression and inhibiting Wnt/β-catenin signaling.https://doi.org/10.1177/0300060520928831 |
| spellingShingle | Jie Chen Chun-Yan Kang Zhao-Xia Niu Hui-Cong Zhou Hong-Mei Yang A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells Journal of International Medical Research |
| title | A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells |
| title_full | A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells |
| title_fullStr | A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells |
| title_full_unstemmed | A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells |
| title_short | A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells |
| title_sort | chalcone inhibits the growth and metastasis of kyse 4 esophageal cancer cells |
| url | https://doi.org/10.1177/0300060520928831 |
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