Exposure to Air Pollutants Increases the Risk of Chronic Rhinosinusitis in Taiwan Residents
Air pollution triggers a tissue-specific inflammatory response. However, studies on the association between exposure to air pollutants and chronic rhinosinusitis (CRS) risk remain limited. Thus, we conducted this nationwide study to define the association between air pollution and CRS. We used the L...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/10/4/173 |
| _version_ | 1797409206969565184 |
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| author | Shih-Wei Chen Han-Jie Lin Stella Chin-Shaw Tsai Cheng-Li Lin Chung Y. Hsu Tsai-Ling Hsieh Chuan-Mu Chen Kuang-Hsi Chang |
| author_facet | Shih-Wei Chen Han-Jie Lin Stella Chin-Shaw Tsai Cheng-Li Lin Chung Y. Hsu Tsai-Ling Hsieh Chuan-Mu Chen Kuang-Hsi Chang |
| author_sort | Shih-Wei Chen |
| collection | DOAJ |
| description | Air pollution triggers a tissue-specific inflammatory response. However, studies on the association between exposure to air pollutants and chronic rhinosinusitis (CRS) risk remain limited. Thus, we conducted this nationwide study to define the association between air pollution and CRS. We used the Longitudinal Health Insurance Database (LHID) and Taiwan Air Quality-Monitoring Database (TAQMD) to conduct a population-based cohort study. Study participants were recruited from the LHID, a data subset of the National Health Insurance Research Database that randomly sampled one million individuals. TAQMD has been an air pollutant database since 1998. In univariate and multivariate Cox proportional hazards regression models, adjusted hazard ratios (aHRs) and 95% CIs of CRS in five air pollutants were accounted. We adjusted for age, sex, urbanization level, insurance fee, comorbidities, and pollutant levels in the multivariate model. The total number of participants enrolled in this study was 160,504. The average age was 40.46 ± 14.62 years; males constituted 43.8% of the total participants. The percentages of alcoholism, tobacco dependence, and COPD were 1.5%, 2.8%, and 28.3%, respectively. After adjustment for age, sex, urbanization level, insurance fee, and comorbidities, the highest levels of air pollutants, including PM<sub>2.5</sub> (aHR = 1.14, 95% CI = 1.06–1.22), NO<sub>2</sub> (aHR = 1.07, 95% CI = 1.00–1.15), and PM<sub>10</sub> (aHR = 1.13, 95% CI = 1.05–1.21) had a significantly greater CRS risk; we selected the lower concentration as the reference but did not correlate with CO. We found a significantly increased risk of CRS in residents with air pollutant exposure. |
| first_indexed | 2024-03-09T04:10:01Z |
| format | Article |
| id | doaj.art-ca0e76e78cdb482886bf0c6c55d25471 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T04:10:01Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-ca0e76e78cdb482886bf0c6c55d254712023-12-03T14:01:31ZengMDPI AGToxics2305-63042022-04-0110417310.3390/toxics10040173Exposure to Air Pollutants Increases the Risk of Chronic Rhinosinusitis in Taiwan ResidentsShih-Wei Chen0Han-Jie Lin1Stella Chin-Shaw Tsai2Cheng-Li Lin3Chung Y. Hsu4Tsai-Ling Hsieh5Chuan-Mu Chen6Kuang-Hsi Chang7Department of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, TaiwanDepartment of Otolaryngology, Tungs’ Taichung MetroHarbor Hospital, Taichung 435, TaiwanDepartment of Otolaryngology, Tungs’ Taichung MetroHarbor Hospital, Taichung 435, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung 404, TaiwanGraduate Institute of Clinical Medical Science, China Medical University, Taichung 404, TaiwanDepartment of Otolaryngology, Tungs’ Taichung MetroHarbor Hospital, Taichung 435, TaiwanDepartment of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, TaiwanDepartment of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, TaiwanAir pollution triggers a tissue-specific inflammatory response. However, studies on the association between exposure to air pollutants and chronic rhinosinusitis (CRS) risk remain limited. Thus, we conducted this nationwide study to define the association between air pollution and CRS. We used the Longitudinal Health Insurance Database (LHID) and Taiwan Air Quality-Monitoring Database (TAQMD) to conduct a population-based cohort study. Study participants were recruited from the LHID, a data subset of the National Health Insurance Research Database that randomly sampled one million individuals. TAQMD has been an air pollutant database since 1998. In univariate and multivariate Cox proportional hazards regression models, adjusted hazard ratios (aHRs) and 95% CIs of CRS in five air pollutants were accounted. We adjusted for age, sex, urbanization level, insurance fee, comorbidities, and pollutant levels in the multivariate model. The total number of participants enrolled in this study was 160,504. The average age was 40.46 ± 14.62 years; males constituted 43.8% of the total participants. The percentages of alcoholism, tobacco dependence, and COPD were 1.5%, 2.8%, and 28.3%, respectively. After adjustment for age, sex, urbanization level, insurance fee, and comorbidities, the highest levels of air pollutants, including PM<sub>2.5</sub> (aHR = 1.14, 95% CI = 1.06–1.22), NO<sub>2</sub> (aHR = 1.07, 95% CI = 1.00–1.15), and PM<sub>10</sub> (aHR = 1.13, 95% CI = 1.05–1.21) had a significantly greater CRS risk; we selected the lower concentration as the reference but did not correlate with CO. We found a significantly increased risk of CRS in residents with air pollutant exposure.https://www.mdpi.com/2305-6304/10/4/173air pollutionchronic rhinosinusitislongitudinal health insurance databaseTaiwan air quality-monitoring database |
| spellingShingle | Shih-Wei Chen Han-Jie Lin Stella Chin-Shaw Tsai Cheng-Li Lin Chung Y. Hsu Tsai-Ling Hsieh Chuan-Mu Chen Kuang-Hsi Chang Exposure to Air Pollutants Increases the Risk of Chronic Rhinosinusitis in Taiwan Residents Toxics air pollution chronic rhinosinusitis longitudinal health insurance database Taiwan air quality-monitoring database |
| title | Exposure to Air Pollutants Increases the Risk of Chronic Rhinosinusitis in Taiwan Residents |
| title_full | Exposure to Air Pollutants Increases the Risk of Chronic Rhinosinusitis in Taiwan Residents |
| title_fullStr | Exposure to Air Pollutants Increases the Risk of Chronic Rhinosinusitis in Taiwan Residents |
| title_full_unstemmed | Exposure to Air Pollutants Increases the Risk of Chronic Rhinosinusitis in Taiwan Residents |
| title_short | Exposure to Air Pollutants Increases the Risk of Chronic Rhinosinusitis in Taiwan Residents |
| title_sort | exposure to air pollutants increases the risk of chronic rhinosinusitis in taiwan residents |
| topic | air pollution chronic rhinosinusitis longitudinal health insurance database Taiwan air quality-monitoring database |
| url | https://www.mdpi.com/2305-6304/10/4/173 |
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