Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis
Ageing is a complex process which implies the accumulation of molecular, cellular and organ damage, leading to an increased vulnerability to disease. In Western societies, the increase in the elderly population, which is accompanied by ageing-associated pathologies such as cardiovascular and mental...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5788 |
| _version_ | 1797532284270673920 |
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| author | Beatrix Paton Manuel Suarez Pol Herrero Núria Canela |
| author_facet | Beatrix Paton Manuel Suarez Pol Herrero Núria Canela |
| author_sort | Beatrix Paton |
| collection | DOAJ |
| description | Ageing is a complex process which implies the accumulation of molecular, cellular and organ damage, leading to an increased vulnerability to disease. In Western societies, the increase in the elderly population, which is accompanied by ageing-associated pathologies such as cardiovascular and mental diseases, is becoming an increasing economic and social burden for governments. In order to prevent, treat and determine which subjects are more likely to develop these age-related diseases, predictive biomarkers are required. In this sense, some studies suggest that glycans have a potential role as disease biomarkers, as they modify the functions of proteins and take part in intra- and intercellular biological processes. As the glycome reflects the real-time status of these interactions, its characterisation can provide potential diagnostic and prognostic biomarkers for multifactorial diseases. This review gathers the alterations in protein glycosylation profiles that are associated with ageing and age-related diseases, such as cancer, type 2 diabetes mellitus, metabolic syndrome and several chronic inflammatory diseases. Furthermore, the review includes the available techniques for the determination and characterisation of glycans, such as liquid chromatography, electrophoresis, nuclear magnetic resonance and mass spectrometry. |
| first_indexed | 2024-03-10T10:56:55Z |
| format | Article |
| id | doaj.art-ca121a7cbe324628ba631533b576f3ba |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:56:55Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ca121a7cbe324628ba631533b576f3ba2023-11-21T21:49:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211578810.3390/ijms22115788Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan AnalysisBeatrix Paton0Manuel Suarez1Pol Herrero2Núria Canela3Eurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences, Joint Unit Eurecat-Universitat Rovira i Virgili, Unique Scientific and Technical Infrastructure (ICTS), 43204 Reus, SpainNutrigenomics Research Group, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, 43007 Tarragona, SpainEurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences, Joint Unit Eurecat-Universitat Rovira i Virgili, Unique Scientific and Technical Infrastructure (ICTS), 43204 Reus, SpainEurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences, Joint Unit Eurecat-Universitat Rovira i Virgili, Unique Scientific and Technical Infrastructure (ICTS), 43204 Reus, SpainAgeing is a complex process which implies the accumulation of molecular, cellular and organ damage, leading to an increased vulnerability to disease. In Western societies, the increase in the elderly population, which is accompanied by ageing-associated pathologies such as cardiovascular and mental diseases, is becoming an increasing economic and social burden for governments. In order to prevent, treat and determine which subjects are more likely to develop these age-related diseases, predictive biomarkers are required. In this sense, some studies suggest that glycans have a potential role as disease biomarkers, as they modify the functions of proteins and take part in intra- and intercellular biological processes. As the glycome reflects the real-time status of these interactions, its characterisation can provide potential diagnostic and prognostic biomarkers for multifactorial diseases. This review gathers the alterations in protein glycosylation profiles that are associated with ageing and age-related diseases, such as cancer, type 2 diabetes mellitus, metabolic syndrome and several chronic inflammatory diseases. Furthermore, the review includes the available techniques for the determination and characterisation of glycans, such as liquid chromatography, electrophoresis, nuclear magnetic resonance and mass spectrometry.https://www.mdpi.com/1422-0067/22/11/5788ageingglycosylation<i>n</i>-glycanage-related diseaseglycan analysismass spectrometry |
| spellingShingle | Beatrix Paton Manuel Suarez Pol Herrero Núria Canela Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis International Journal of Molecular Sciences ageing glycosylation <i>n</i>-glycan age-related disease glycan analysis mass spectrometry |
| title | Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis |
| title_full | Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis |
| title_fullStr | Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis |
| title_full_unstemmed | Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis |
| title_short | Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis |
| title_sort | glycosylation biomarkers associated with age related diseases and current methods for glycan analysis |
| topic | ageing glycosylation <i>n</i>-glycan age-related disease glycan analysis mass spectrometry |
| url | https://www.mdpi.com/1422-0067/22/11/5788 |
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