Polar pattern formation induced by contact following locomotion in a multicellular system
Biophysical mechanisms underlying collective cell migration of eukaryotic cells have been studied extensively in recent years. One mechanism that induces cells to correlate their motions is contact inhibition of locomotion, by which cells migrating away from the contact site. Here, we report that ta...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-04-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/53609 |
| _version_ | 1811201277279862784 |
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| author | Masayuki Hayakawa Tetsuya Hiraiwa Yuko Wada Hidekazu Kuwayama Tatsuo Shibata |
| author_facet | Masayuki Hayakawa Tetsuya Hiraiwa Yuko Wada Hidekazu Kuwayama Tatsuo Shibata |
| author_sort | Masayuki Hayakawa |
| collection | DOAJ |
| description | Biophysical mechanisms underlying collective cell migration of eukaryotic cells have been studied extensively in recent years. One mechanism that induces cells to correlate their motions is contact inhibition of locomotion, by which cells migrating away from the contact site. Here, we report that tail-following behavior at the contact site, termed contact following locomotion (CFL), can induce a non-trivial collective behavior in migrating cells. We show the emergence of a traveling band showing polar order in a mutant Dictyostelium cell that lacks chemotactic activity. We find that CFL is the cell–cell interaction underlying this phenomenon, enabling a theoretical description of how this traveling band forms. We further show that the polar order phase consists of subpopulations that exhibit characteristic transversal motions with respect to the direction of band propagation. These findings describe a novel mechanism of collective cell migration involving cell–cell interactions capable of inducing traveling band with polar order. |
| first_indexed | 2024-04-12T02:19:24Z |
| format | Article |
| id | doaj.art-ca1642cacbc745ec8ff1e566a92cb3d9 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:19:24Z |
| publishDate | 2020-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ca1642cacbc745ec8ff1e566a92cb3d92022-12-22T03:52:11ZengeLife Sciences Publications LtdeLife2050-084X2020-04-01910.7554/eLife.53609Polar pattern formation induced by contact following locomotion in a multicellular systemMasayuki Hayakawa0https://orcid.org/0000-0002-9245-9593Tetsuya Hiraiwa1https://orcid.org/0000-0003-3221-345XYuko Wada2Hidekazu Kuwayama3https://orcid.org/0000-0002-4362-0790Tatsuo Shibata4https://orcid.org/0000-0002-9294-9998Laboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research, Kobe, JapanMechanobiology Institute, National University of Singapore, Singapore, Singapore; Universal Biology Institute, University of Tokyo, Tokyo, JapanLaboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research, Kobe, JapanFaculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Ibaraki, JapanLaboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research, Kobe, JapanBiophysical mechanisms underlying collective cell migration of eukaryotic cells have been studied extensively in recent years. One mechanism that induces cells to correlate their motions is contact inhibition of locomotion, by which cells migrating away from the contact site. Here, we report that tail-following behavior at the contact site, termed contact following locomotion (CFL), can induce a non-trivial collective behavior in migrating cells. We show the emergence of a traveling band showing polar order in a mutant Dictyostelium cell that lacks chemotactic activity. We find that CFL is the cell–cell interaction underlying this phenomenon, enabling a theoretical description of how this traveling band forms. We further show that the polar order phase consists of subpopulations that exhibit characteristic transversal motions with respect to the direction of band propagation. These findings describe a novel mechanism of collective cell migration involving cell–cell interactions capable of inducing traveling band with polar order.https://elifesciences.org/articles/53609collective cell migrationself-propelled particlescell-cell contactcell migration |
| spellingShingle | Masayuki Hayakawa Tetsuya Hiraiwa Yuko Wada Hidekazu Kuwayama Tatsuo Shibata Polar pattern formation induced by contact following locomotion in a multicellular system eLife collective cell migration self-propelled particles cell-cell contact cell migration |
| title | Polar pattern formation induced by contact following locomotion in a multicellular system |
| title_full | Polar pattern formation induced by contact following locomotion in a multicellular system |
| title_fullStr | Polar pattern formation induced by contact following locomotion in a multicellular system |
| title_full_unstemmed | Polar pattern formation induced by contact following locomotion in a multicellular system |
| title_short | Polar pattern formation induced by contact following locomotion in a multicellular system |
| title_sort | polar pattern formation induced by contact following locomotion in a multicellular system |
| topic | collective cell migration self-propelled particles cell-cell contact cell migration |
| url | https://elifesciences.org/articles/53609 |
| work_keys_str_mv | AT masayukihayakawa polarpatternformationinducedbycontactfollowinglocomotioninamulticellularsystem AT tetsuyahiraiwa polarpatternformationinducedbycontactfollowinglocomotioninamulticellularsystem AT yukowada polarpatternformationinducedbycontactfollowinglocomotioninamulticellularsystem AT hidekazukuwayama polarpatternformationinducedbycontactfollowinglocomotioninamulticellularsystem AT tatsuoshibata polarpatternformationinducedbycontactfollowinglocomotioninamulticellularsystem |