Dynamics of metabolic parameters partial vascular isolation of liver in rats
This article presents the results of dynamic changes in biochemical parameters in blood and liver of laboratory animals in modeling of partial vascular isolation of liver using a Pringle-maneuver. Indicators of cytolytic syndrome, prooxidantantioxidant and detoxification system function was studied....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2016-06-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/539 |
| _version_ | 1797295567985967104 |
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| author | I. Y. Tsymbalyuk K. A. Popov E. E. Esaulenko K. I. Melkonyan V. V. Malyshko L. V. Tsyplenkov |
| author_facet | I. Y. Tsymbalyuk K. A. Popov E. E. Esaulenko K. I. Melkonyan V. V. Malyshko L. V. Tsyplenkov |
| author_sort | I. Y. Tsymbalyuk |
| collection | DOAJ |
| description | This article presents the results of dynamic changes in biochemical parameters in blood and liver of laboratory animals in modeling of partial vascular isolation of liver using a Pringle-maneuver. Indicators of cytolytic syndrome, prooxidantantioxidant and detoxification system function was studied. Research found evidence of a gradual increase of cytolysis of hepatocytes, intensity of free radical processes, endogenous intoxication, which accompanied of compensatory systems activation by the first 10-15 minutes, and being depleted to 20 minutes of ischemia. These data reveal prospects of metabolic correction of possible complications intraoperative clamping hepatoduodenal bunch by means of antioxidant orientation. Received data may be useful in the formation of concepts about the reasonable time limits of liver vascular isolation. |
| first_indexed | 2024-03-07T21:49:50Z |
| format | Article |
| id | doaj.art-ca1829115be84435bab01a2cddaa6e53 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:49:50Z |
| publishDate | 2016-06-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-ca1829115be84435bab01a2cddaa6e532024-02-25T10:57:18ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442016-06-01313714410.25207/1608-6228-2016-3-137-144539Dynamics of metabolic parameters partial vascular isolation of liver in ratsI. Y. Tsymbalyuk0K. A. Popov1E. E. Esaulenko2K. I. Melkonyan3V. V. Malyshko4L. V. Tsyplenkov5Kuban state medical universityKuban state medical universityKuban state medical universityKuban state medical universityKuban state medical universityKuban state medical universityThis article presents the results of dynamic changes in biochemical parameters in blood and liver of laboratory animals in modeling of partial vascular isolation of liver using a Pringle-maneuver. Indicators of cytolytic syndrome, prooxidantantioxidant and detoxification system function was studied. Research found evidence of a gradual increase of cytolysis of hepatocytes, intensity of free radical processes, endogenous intoxication, which accompanied of compensatory systems activation by the first 10-15 minutes, and being depleted to 20 minutes of ischemia. These data reveal prospects of metabolic correction of possible complications intraoperative clamping hepatoduodenal bunch by means of antioxidant orientation. Received data may be useful in the formation of concepts about the reasonable time limits of liver vascular isolation.https://ksma.elpub.ru/jour/article/view/539сосудистая изоляция печеницитолиз гепатоцитовантиоксидантная системаокислительный стрессэндогенная интоксикацияliver vascular isolationcytolysis of hepatocytesantioxidant systemoxidative stressendogenous intoxication |
| spellingShingle | I. Y. Tsymbalyuk K. A. Popov E. E. Esaulenko K. I. Melkonyan V. V. Malyshko L. V. Tsyplenkov Dynamics of metabolic parameters partial vascular isolation of liver in rats Кубанский научный медицинский вестник сосудистая изоляция печени цитолиз гепатоцитов антиоксидантная система окислительный стресс эндогенная интоксикация liver vascular isolation cytolysis of hepatocytes antioxidant system oxidative stress endogenous intoxication |
| title | Dynamics of metabolic parameters partial vascular isolation of liver in rats |
| title_full | Dynamics of metabolic parameters partial vascular isolation of liver in rats |
| title_fullStr | Dynamics of metabolic parameters partial vascular isolation of liver in rats |
| title_full_unstemmed | Dynamics of metabolic parameters partial vascular isolation of liver in rats |
| title_short | Dynamics of metabolic parameters partial vascular isolation of liver in rats |
| title_sort | dynamics of metabolic parameters partial vascular isolation of liver in rats |
| topic | сосудистая изоляция печени цитолиз гепатоцитов антиоксидантная система окислительный стресс эндогенная интоксикация liver vascular isolation cytolysis of hepatocytes antioxidant system oxidative stress endogenous intoxication |
| url | https://ksma.elpub.ru/jour/article/view/539 |
| work_keys_str_mv | AT iytsymbalyuk dynamicsofmetabolicparameterspartialvascularisolationofliverinrats AT kapopov dynamicsofmetabolicparameterspartialvascularisolationofliverinrats AT eeesaulenko dynamicsofmetabolicparameterspartialvascularisolationofliverinrats AT kimelkonyan dynamicsofmetabolicparameterspartialvascularisolationofliverinrats AT vvmalyshko dynamicsofmetabolicparameterspartialvascularisolationofliverinrats AT lvtsyplenkov dynamicsofmetabolicparameterspartialvascularisolationofliverinrats |