Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failure
Objective: To identify the clinical and laboratory predictors of short-term mortality in patients with acute heart failure (AHF). Subjects and methods: We conducted a prospective, single center study on 120 consecutive patients presented with acute heart failure to the emergency department. All pati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-09-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110260816301168 |
| _version_ | 1818041946807992320 |
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| author | Ahmad Tageldien Abdellah Alaa Desouky Mohamed Hamdy Ali Hendawi Magdi Ali Omera |
| author_facet | Ahmad Tageldien Abdellah Alaa Desouky Mohamed Hamdy Ali Hendawi Magdi Ali Omera |
| author_sort | Ahmad Tageldien Abdellah |
| collection | DOAJ |
| description | Objective: To identify the clinical and laboratory predictors of short-term mortality in patients with acute heart failure (AHF).
Subjects and methods: We conducted a prospective, single center study on 120 consecutive patients presented with acute heart failure to the emergency department. All patients had clinical, laboratory, electrocardiographic and echocardiographic evaluation. Short-term mortality was reported within 30 days of presentation.
Results: Mean age was 59.29 ± 10.1 years, 55.8% were males and 50.8% were smokers. The common AHF presentations were dyspnea (91.7%), chest tightness (62.5%) and lower limb edema (54.2%). Ischemic heart disease, diabetes and hypertension were present in 72.5%, 43.3% and 35% of patients, respectively.
Short-term mortality was reported in 29 patients (24.16%); most of them died in-hospital (19 patients, 65.52%). The following parameters were significantly associated with short-term mortality: hypoxia (P < 0.001), tachycardia (P < 0.01), raised jugular venous pressure (JVP) (P < 0.001), low systolic blood pressure (P < 0.01), prolonged PR interval (P < 0.007), atrial fibrillation (AF) (P < 0.038), left bundle branch block (LBBB) (P < 0.04), impaired kidney function (P < 0.007), anemia (P < 0.029), hyponatremia (P < 0.006), hypoalbuminemia (P < 0.005), dilated left ventricle (LV) (P < 0.001), low LV ejection fraction (LVEF) (P < 0.001), and dilated left atrium (LA) (P < 0.002).
ROC curve analysis showed that low LVEF (≤24%), dilated LV end diastolic diameter (LVESD) ≥ 66.5 mm, dilated LV end systolic diameter (LVESD) ≥ 53.5 mm, dilated LA diameter ≥ 48 mm, increased serum creatinine ≥ 1.6 mg/dl, and decreased serum albumin ≤ 3 g/dl can significantly predict short-term mortality in patients with acute heart failure.
Conclusion: Variable clinical, laboratory, electrocardiographic and echocardiographic parameters were associated with short-term mortality. Our study showed that low LVEF, dilated LV diameter, dilated LA diameter, impaired kidney function and low serum albumin can predict short-term mortality in patients with acute heart failure. |
| first_indexed | 2024-12-10T08:38:30Z |
| format | Article |
| id | doaj.art-ca1864faf7cc42f29364cf3ddaf96226 |
| institution | Directory Open Access Journal |
| issn | 1110-2608 |
| language | English |
| last_indexed | 2024-12-10T08:38:30Z |
| publishDate | 2017-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-ca1864faf7cc42f29364cf3ddaf962262022-12-22T01:55:54ZengSpringerOpenThe Egyptian Heart Journal1110-26082017-09-0169320120810.1016/j.ehj.2017.02.003Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failureAhmad Tageldien Abdellah0Alaa Desouky Mohamed1Hamdy Ali Hendawi2Magdi Ali Omera3Cardiovascular Medicine Department, Suez Canal University, EgyptEmergency Department, Suez Canal University, EgyptAnasethia and Intensive Care Department, Suez Canal University, EgyptAnasethia and Intensive Care Department, Suez Canal University, EgyptObjective: To identify the clinical and laboratory predictors of short-term mortality in patients with acute heart failure (AHF). Subjects and methods: We conducted a prospective, single center study on 120 consecutive patients presented with acute heart failure to the emergency department. All patients had clinical, laboratory, electrocardiographic and echocardiographic evaluation. Short-term mortality was reported within 30 days of presentation. Results: Mean age was 59.29 ± 10.1 years, 55.8% were males and 50.8% were smokers. The common AHF presentations were dyspnea (91.7%), chest tightness (62.5%) and lower limb edema (54.2%). Ischemic heart disease, diabetes and hypertension were present in 72.5%, 43.3% and 35% of patients, respectively. Short-term mortality was reported in 29 patients (24.16%); most of them died in-hospital (19 patients, 65.52%). The following parameters were significantly associated with short-term mortality: hypoxia (P < 0.001), tachycardia (P < 0.01), raised jugular venous pressure (JVP) (P < 0.001), low systolic blood pressure (P < 0.01), prolonged PR interval (P < 0.007), atrial fibrillation (AF) (P < 0.038), left bundle branch block (LBBB) (P < 0.04), impaired kidney function (P < 0.007), anemia (P < 0.029), hyponatremia (P < 0.006), hypoalbuminemia (P < 0.005), dilated left ventricle (LV) (P < 0.001), low LV ejection fraction (LVEF) (P < 0.001), and dilated left atrium (LA) (P < 0.002). ROC curve analysis showed that low LVEF (≤24%), dilated LV end diastolic diameter (LVESD) ≥ 66.5 mm, dilated LV end systolic diameter (LVESD) ≥ 53.5 mm, dilated LA diameter ≥ 48 mm, increased serum creatinine ≥ 1.6 mg/dl, and decreased serum albumin ≤ 3 g/dl can significantly predict short-term mortality in patients with acute heart failure. Conclusion: Variable clinical, laboratory, electrocardiographic and echocardiographic parameters were associated with short-term mortality. Our study showed that low LVEF, dilated LV diameter, dilated LA diameter, impaired kidney function and low serum albumin can predict short-term mortality in patients with acute heart failure.http://www.sciencedirect.com/science/article/pii/S1110260816301168Acute heart failurePredictorsShort termMortalityEgypt |
| spellingShingle | Ahmad Tageldien Abdellah Alaa Desouky Mohamed Hamdy Ali Hendawi Magdi Ali Omera Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failure The Egyptian Heart Journal Acute heart failure Predictors Short term Mortality Egypt |
| title | Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failure |
| title_full | Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failure |
| title_fullStr | Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failure |
| title_full_unstemmed | Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failure |
| title_short | Clinical and laboratory characteristics of short-term mortality in Egyptian patients with acute heart failure |
| title_sort | clinical and laboratory characteristics of short term mortality in egyptian patients with acute heart failure |
| topic | Acute heart failure Predictors Short term Mortality Egypt |
| url | http://www.sciencedirect.com/science/article/pii/S1110260816301168 |
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