Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

Background Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) has been demonstrated as a negative intracellular immune checkpoint in mediating antitumor immunity in studies with HPK1 knockout and kinase dead mice. Pharmacological inhibition of HPK1 is desirable to investigate the role of HPK1 in hum...

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Bibliographic Details
Main Authors: Chan Gao, Michael Quigley, Dandan Zhao, Jennifer Koenitzer, Dan You, Stephen Hillerman, Gregory Locke, Charu Chaudhry, Caitlyn Stromko, Anwar Murtaza, Yi Fan, Yali Chen, Stephanie Briceno, Elizabeth Duperret, Johnni Gullo-Brown, John Feder, Joshua Curtin, Andrew P Degnan, Godwin Kumi, Mark Wittman, Benjamin M Johnson, Karen E Parrish, Giridharan Gokulrangan, John T Hunt, Luisa Salter-Cid, Emma Lees, Jinqi Liu
Format: Article
Language:English
Published: BMJ Publishing Group 2021-01-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/1/e001402.full

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