MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes
Abstract Introduction MCP‐1 and eotaxin‐1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) deme...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2016.05.004 |
| _version_ | 1828190379694882816 |
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| author | Brianne M. Bettcher Ryan Fitch Matthew J. Wynn Matthew A. Lalli Jonathan Elofson Laura Jastrzab Laura Mitic Zachary A. Miller Gil D. Rabinovici Bruce L. Miller Aimee W. Kao Kenneth S. Kosik Joel H. Kramer |
| author_facet | Brianne M. Bettcher Ryan Fitch Matthew J. Wynn Matthew A. Lalli Jonathan Elofson Laura Jastrzab Laura Mitic Zachary A. Miller Gil D. Rabinovici Bruce L. Miller Aimee W. Kao Kenneth S. Kosik Joel H. Kramer |
| author_sort | Brianne M. Bettcher |
| collection | DOAJ |
| description | Abstract Introduction MCP‐1 and eotaxin‐1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. Methods MCP‐1 and eotaxin‐1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained. Results An interaction was noted between MCP‐1 and eotaxin‐1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non‐chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains. Discussion These results suggest a potentially selective role for MCP‐1 and eotaxin‐1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes. |
| first_indexed | 2024-04-12T08:21:21Z |
| format | Article |
| id | doaj.art-ca18ddfd0c2c49a89d1a08cae026cec8 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-12T08:21:21Z |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-ca18ddfd0c2c49a89d1a08cae026cec82022-12-22T03:40:35ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292016-01-0131919710.1016/j.dadm.2016.05.004MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypesBrianne M. Bettcher0Ryan Fitch1Matthew J. Wynn2Matthew A. Lalli3Jonathan Elofson4Laura Jastrzab5Laura Mitic6Zachary A. Miller7Gil D. Rabinovici8Bruce L. Miller9Aimee W. Kao10Kenneth S. Kosik11Joel H. Kramer12Rocky Mountain Alzheimer's Disease CenterDepartments of Neurosurgery and NeurologyUniversity of Colorado Anschutz School of MedicineAuroraCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSANeuroscience Research InstituteDepartment of Molecular, Cellular, and Developmental BiologyUniversity of CaliforniaSanta BarbaraSanta BarbaraCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSANeuroscience Research InstituteDepartment of Molecular, Cellular, and Developmental BiologyUniversity of CaliforniaSanta BarbaraSanta BarbaraCAUSAMemory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSAAbstract Introduction MCP‐1 and eotaxin‐1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. Methods MCP‐1 and eotaxin‐1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained. Results An interaction was noted between MCP‐1 and eotaxin‐1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non‐chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains. Discussion These results suggest a potentially selective role for MCP‐1 and eotaxin‐1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes.https://doi.org/10.1016/j.dadm.2016.05.004InflammationNeuropsychologyChemokinesNeuroimagingEpisodic memory |
| spellingShingle | Brianne M. Bettcher Ryan Fitch Matthew J. Wynn Matthew A. Lalli Jonathan Elofson Laura Jastrzab Laura Mitic Zachary A. Miller Gil D. Rabinovici Bruce L. Miller Aimee W. Kao Kenneth S. Kosik Joel H. Kramer MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Inflammation Neuropsychology Chemokines Neuroimaging Episodic memory |
| title | MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes |
| title_full | MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes |
| title_fullStr | MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes |
| title_full_unstemmed | MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes |
| title_short | MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes |
| title_sort | mcp 1 and eotaxin 1 selectively and negatively associate with memory in mci and alzheimer s disease dementia phenotypes |
| topic | Inflammation Neuropsychology Chemokines Neuroimaging Episodic memory |
| url | https://doi.org/10.1016/j.dadm.2016.05.004 |
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