Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new cases by the year 2030. The current treatment modalities with the usage of chemo drugs such as FOLFOX and FOLFIRI, su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/20/10/2454 |
| _version_ | 1811341940867727360 |
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| author | Nor Isnida Ismail Iekhsan Othman Faridah Abas Nordin H. Lajis Rakesh Naidu |
| author_facet | Nor Isnida Ismail Iekhsan Othman Faridah Abas Nordin H. Lajis Rakesh Naidu |
| author_sort | Nor Isnida Ismail |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new cases by the year 2030. The current treatment modalities with the usage of chemo drugs such as FOLFOX and FOLFIRI, surgery and radiotherapy, which are usually accompanied with major side effects, are rarely cured along with poor survival rate and at higher recurrence outcome. This trigger the needs of exploring new natural compounds with anti-cancer properties which possess fewer side effects. Curcumin, a common spice used in ancient medicine was found to induce apoptosis by targeting various molecules and signaling pathways involved in CRC. Disruption of the homeostatic balance between cell proliferation and apoptosis could be one of the promoting factors in colorectal cancer progression. In this review, we describe the current knowledge of apoptosis regulation by curcumin in CRC with regard to molecular targets and associated signaling pathways. |
| first_indexed | 2024-04-13T19:02:58Z |
| format | Article |
| id | doaj.art-ca18df9c300f40238c1d20944e6b83d4 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T19:02:58Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ca18df9c300f40238c1d20944e6b83d42022-12-22T02:34:03ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-05-012010245410.3390/ijms20102454ijms20102454Mechanism of Apoptosis Induced by Curcumin in Colorectal CancerNor Isnida Ismail0Iekhsan Othman1Faridah Abas2Nordin H. Lajis3Rakesh Naidu4Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway Darul Ehsan, MalaysiaJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway Darul Ehsan, MalaysiaLaboratory of Natural Products, Faculty of Science, University Putra Malaysia, UPM, 43400 Serdang, MalaysiaLaboratory of Natural Products, Faculty of Science, University Putra Malaysia, UPM, 43400 Serdang, MalaysiaJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway Darul Ehsan, MalaysiaColorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new cases by the year 2030. The current treatment modalities with the usage of chemo drugs such as FOLFOX and FOLFIRI, surgery and radiotherapy, which are usually accompanied with major side effects, are rarely cured along with poor survival rate and at higher recurrence outcome. This trigger the needs of exploring new natural compounds with anti-cancer properties which possess fewer side effects. Curcumin, a common spice used in ancient medicine was found to induce apoptosis by targeting various molecules and signaling pathways involved in CRC. Disruption of the homeostatic balance between cell proliferation and apoptosis could be one of the promoting factors in colorectal cancer progression. In this review, we describe the current knowledge of apoptosis regulation by curcumin in CRC with regard to molecular targets and associated signaling pathways.https://www.mdpi.com/1422-0067/20/10/2454cell deathapoptosiscurcumincolorectal cancer |
| spellingShingle | Nor Isnida Ismail Iekhsan Othman Faridah Abas Nordin H. Lajis Rakesh Naidu Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer International Journal of Molecular Sciences cell death apoptosis curcumin colorectal cancer |
| title | Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer |
| title_full | Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer |
| title_fullStr | Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer |
| title_full_unstemmed | Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer |
| title_short | Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer |
| title_sort | mechanism of apoptosis induced by curcumin in colorectal cancer |
| topic | cell death apoptosis curcumin colorectal cancer |
| url | https://www.mdpi.com/1422-0067/20/10/2454 |
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