The Jumonji family: past, present and future of histone demethylases in cancer
The first Jumonji gene was cloned in 1995 by Takeuchi et al. [Takeuchi T, Yamazaki Y, Katoh-Fukui Y, Tsuchiya R, Kondo S, Motoyama J, Higashinakagawa T. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev 1995; 9: 1211–22.]. Several genes sharing similar b...
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2014-06-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2014-0010 |
| _version_ | 1818677767414218752 |
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| author | Franci Gianluigi Ciotta Alfonso Altucci Lucia |
| author_facet | Franci Gianluigi Ciotta Alfonso Altucci Lucia |
| author_sort | Franci Gianluigi |
| collection | DOAJ |
| description | The first Jumonji gene was cloned in 1995 by Takeuchi et al. [Takeuchi T, Yamazaki Y, Katoh-Fukui Y, Tsuchiya R, Kondo S, Motoyama J, Higashinakagawa T. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev 1995; 9: 1211–22.]. Several genes sharing similar biological features have since been discovered, and are currently grouped into the JMJ family. Interestingly, their deregulation has been associated with cardiac disease, obesity, neurological disorders and cancer. One of the mechanisms underlying their function is gene expression modulation via histone post-translational modifications (PTMs). Increasing evidence of Jumonji deregulation in tumours such as colon, prostate, haematological and breast cancer is continually emerging, hence the need to acquire a better understanding. The Genesapiens.org database of patient arrays allows target expression levels to be investigated in a wide range of cancers, corroborating and extending the role of the JMJ family. Here, we provide an overview of the expression profile and regulation of JMJ family members in cancer, examining the most recent literature in the light of analyses drawn from this database. |
| first_indexed | 2024-12-17T09:04:36Z |
| format | Article |
| id | doaj.art-ca197e84e3bb4063850dd9707eb58327 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T09:04:36Z |
| publishDate | 2014-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-ca197e84e3bb4063850dd9707eb583272022-12-21T21:55:34ZengDe GruyterBiomolecular Concepts1868-50211868-503X2014-06-015320922410.1515/bmc-2014-0010The Jumonji family: past, present and future of histone demethylases in cancerFranci Gianluigi0Ciotta Alfonso1Altucci LuciaDipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, I-80138 Napoli, ItalyDipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, I-80138 Napoli, ItalyThe first Jumonji gene was cloned in 1995 by Takeuchi et al. [Takeuchi T, Yamazaki Y, Katoh-Fukui Y, Tsuchiya R, Kondo S, Motoyama J, Higashinakagawa T. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev 1995; 9: 1211–22.]. Several genes sharing similar biological features have since been discovered, and are currently grouped into the JMJ family. Interestingly, their deregulation has been associated with cardiac disease, obesity, neurological disorders and cancer. One of the mechanisms underlying their function is gene expression modulation via histone post-translational modifications (PTMs). Increasing evidence of Jumonji deregulation in tumours such as colon, prostate, haematological and breast cancer is continually emerging, hence the need to acquire a better understanding. The Genesapiens.org database of patient arrays allows target expression levels to be investigated in a wide range of cancers, corroborating and extending the role of the JMJ family. Here, we provide an overview of the expression profile and regulation of JMJ family members in cancer, examining the most recent literature in the light of analyses drawn from this database.https://doi.org/10.1515/bmc-2014-0010cancerchromatin-modulating drugsepigeneticshistone demethylasesjumonji family. |
| spellingShingle | Franci Gianluigi Ciotta Alfonso Altucci Lucia The Jumonji family: past, present and future of histone demethylases in cancer Biomolecular Concepts cancer chromatin-modulating drugs epigenetics histone demethylases jumonji family. |
| title | The Jumonji family: past, present and future of histone demethylases in cancer |
| title_full | The Jumonji family: past, present and future of histone demethylases in cancer |
| title_fullStr | The Jumonji family: past, present and future of histone demethylases in cancer |
| title_full_unstemmed | The Jumonji family: past, present and future of histone demethylases in cancer |
| title_short | The Jumonji family: past, present and future of histone demethylases in cancer |
| title_sort | jumonji family past present and future of histone demethylases in cancer |
| topic | cancer chromatin-modulating drugs epigenetics histone demethylases jumonji family. |
| url | https://doi.org/10.1515/bmc-2014-0010 |
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