Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab
A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
|
| Series: | Bone Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187223000359 |
| _version_ | 1797798098722881536 |
|---|---|
| author | Signe Sparre Beck-Nielsen Henrik Hasle Akmal Safwat Kestutis Valancius Bente Langdahl Ebbe Stender Hansen |
| author_facet | Signe Sparre Beck-Nielsen Henrik Hasle Akmal Safwat Kestutis Valancius Bente Langdahl Ebbe Stender Hansen |
| author_sort | Signe Sparre Beck-Nielsen |
| collection | DOAJ |
| description | A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children. Denosumab treatment for 21 months reduced and stabilized tumour size, the girl became pain free with asymptomatic side effects as mild hypocalcemia, hypophosphatemia and sclerosis of newly formed bone. |
| first_indexed | 2024-03-13T03:58:25Z |
| format | Article |
| id | doaj.art-ca1a40a5baf04e55bea655437e9fb4f6 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-03-13T03:58:25Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-ca1a40a5baf04e55bea655437e9fb4f62023-06-22T05:03:18ZengElsevierBone Reports2352-18722023-06-0118101687Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumabSigne Sparre Beck-Nielsen0Henrik Hasle1Akmal Safwat2Kestutis Valancius3Bente Langdahl4Ebbe Stender Hansen5Centre for Rare Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulvard 99, DK-8200 Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulvard 82, DK-8200 Aarhus N, Denmark; Corresponding author at: Centre for Rare Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulvard 99, DK-8200 Aarhus N, Denmark.Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulvard 82, DK-8200 Aarhus N, Denmark; Paediatrics and Adolescent Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulvard 99, DK-8200 Aarhus N, DenmarkOncology Department and Danish Center for Particle Therapy, Aarhus University Hospital, Palle Juul-Jensens Boulvard 99, DK-8200 Aarhus N, DenmarkSpine Surgery Unit, Department of Orthopedic Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulvard 99, DK-8200 Aarhus N, DenmarkDepartment of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulvard 82, DK-8200 Aarhus N, Denmark; Department of Endocrinology, Aarhus University Hospital, Palle Juul-Jensens Boulvard 99, DK-8200 Aarhus N, DenmarkSpine Surgery Unit, Department of Orthopedic Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulvard 99, DK-8200 Aarhus N, DenmarkA giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children. Denosumab treatment for 21 months reduced and stabilized tumour size, the girl became pain free with asymptomatic side effects as mild hypocalcemia, hypophosphatemia and sclerosis of newly formed bone.http://www.sciencedirect.com/science/article/pii/S2352187223000359Giant cell tumour of boneOs sacrumPrepubertalZoledronateDenosumabBone markers |
| spellingShingle | Signe Sparre Beck-Nielsen Henrik Hasle Akmal Safwat Kestutis Valancius Bente Langdahl Ebbe Stender Hansen Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab Bone Reports Giant cell tumour of bone Os sacrum Prepubertal Zoledronate Denosumab Bone markers |
| title | Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab |
| title_full | Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab |
| title_fullStr | Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab |
| title_full_unstemmed | Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab |
| title_short | Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab |
| title_sort | giant cell tumour of bone in os sacrum of a prepubertal girl surgical and medical treatment with zoledronate and denosumab |
| topic | Giant cell tumour of bone Os sacrum Prepubertal Zoledronate Denosumab Bone markers |
| url | http://www.sciencedirect.com/science/article/pii/S2352187223000359 |
| work_keys_str_mv | AT signesparrebecknielsen giantcelltumourofboneinossacrumofaprepubertalgirlsurgicalandmedicaltreatmentwithzoledronateanddenosumab AT henrikhasle giantcelltumourofboneinossacrumofaprepubertalgirlsurgicalandmedicaltreatmentwithzoledronateanddenosumab AT akmalsafwat giantcelltumourofboneinossacrumofaprepubertalgirlsurgicalandmedicaltreatmentwithzoledronateanddenosumab AT kestutisvalancius giantcelltumourofboneinossacrumofaprepubertalgirlsurgicalandmedicaltreatmentwithzoledronateanddenosumab AT bentelangdahl giantcelltumourofboneinossacrumofaprepubertalgirlsurgicalandmedicaltreatmentwithzoledronateanddenosumab AT ebbestenderhansen giantcelltumourofboneinossacrumofaprepubertalgirlsurgicalandmedicaltreatmentwithzoledronateanddenosumab |