Assessment of severity of Parkinson’s disease by optical coherence tomography
Background: Parkinson’s disease (PD) is the second most common movement disorder after essential tremor. Diminished visual acuity, color vision, and contrast sensitivity are also described in PD. Optical coherence tomography (OCT), a producible test for axonal degeneration, helps in prognosticating...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-10-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/45933 |
| _version_ | 1818026596568662016 |
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| author | Bharat Vishnu Reddy Bindela Vamsavardhana Reddy Pidathala Kamalesh Tagadur Nataraju |
| author_facet | Bharat Vishnu Reddy Bindela Vamsavardhana Reddy Pidathala Kamalesh Tagadur Nataraju |
| author_sort | Bharat Vishnu Reddy Bindela |
| collection | DOAJ |
| description | Background: Parkinson’s disease (PD) is the second most common movement disorder after essential tremor. Diminished visual acuity, color vision, and contrast sensitivity are also described in PD. Optical coherence tomography (OCT), a producible test for axonal degeneration, helps in prognosticating diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis.
Aims and Objectives: To assess the severity of Parkinson’s disease with the changes in various variables of OCT. The objective is to evaluate variables such as (RNFL, CMT, TMV) of both eyes with SD – OCT.
Materials and Methods: It is a hospital-based cross-sectional study conducted for a period of 22 months at the department of neurology. A total of 55 PD patients and 30 age- and sex-matched controls were evaluated.
Results: There was a significant difference between patients and controls in average retinal nerve fiber layer (RNFL) and all RNFL quadrants in both the eyes (P<0.001). A significant negative correlation was found between the RNFL thickness and Unified Parkinson’s Disease Rating Scale (UPDRS) motor score and Hoehn and Yahr (H&Y) score in both the eyes (P<0.001). A significant negative correlation was found between total macular volume (TMV) and central macular thickness (CMT) with UPDRS motor score in both the eyes (P<0.001). A significant negative correlation was found between CMT and H&Y stage in both the eyes (P<0.001). There was a significant difference between patients and controls in CMT and TMV in both the eyes (P<0.001).
Conclusion: A significant negative correlation between severity and stage of the PD with OCT values was identified, which may suggest the possibility of dopaminergic depletion in the retina corresponding with basal ganglia dopamine depletion. |
| first_indexed | 2024-12-10T04:34:31Z |
| format | Article |
| id | doaj.art-ca1b627daad149e487de4135179b9d62 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-10T04:34:31Z |
| publishDate | 2022-10-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-ca1b627daad149e487de4135179b9d622022-12-22T02:02:02ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-10-011310259265https://doi.org/10.3126/ajms.v13i10.45933Assessment of severity of Parkinson’s disease by optical coherence tomographyBharat Vishnu Reddy Bindela 0https://orcid.org/0000-0003-2338-1654Vamsavardhana Reddy Pidathala 1https://orcid.org/0000-0001-9871-587XKamalesh Tagadur Nataraju 2https://orcid.org/0000-0003-3517-9752Consultant Neurophysician, Jay Vishnu Neuro Centre, Anantapur, Andhra Pradesh, India Associate Professor, Department of Internal Medicine, Apollo Institute of Medical Sciences and Research Centre, Chittoor, Andhra Pradesh, India Associate Professor, Department of General Medicine, SS Institute of Medical Sciences and Research Centre, Davanagere, Karnataka, India Background: Parkinson’s disease (PD) is the second most common movement disorder after essential tremor. Diminished visual acuity, color vision, and contrast sensitivity are also described in PD. Optical coherence tomography (OCT), a producible test for axonal degeneration, helps in prognosticating diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis. Aims and Objectives: To assess the severity of Parkinson’s disease with the changes in various variables of OCT. The objective is to evaluate variables such as (RNFL, CMT, TMV) of both eyes with SD – OCT. Materials and Methods: It is a hospital-based cross-sectional study conducted for a period of 22 months at the department of neurology. A total of 55 PD patients and 30 age- and sex-matched controls were evaluated. Results: There was a significant difference between patients and controls in average retinal nerve fiber layer (RNFL) and all RNFL quadrants in both the eyes (P<0.001). A significant negative correlation was found between the RNFL thickness and Unified Parkinson’s Disease Rating Scale (UPDRS) motor score and Hoehn and Yahr (H&Y) score in both the eyes (P<0.001). A significant negative correlation was found between total macular volume (TMV) and central macular thickness (CMT) with UPDRS motor score in both the eyes (P<0.001). A significant negative correlation was found between CMT and H&Y stage in both the eyes (P<0.001). There was a significant difference between patients and controls in CMT and TMV in both the eyes (P<0.001). Conclusion: A significant negative correlation between severity and stage of the PD with OCT values was identified, which may suggest the possibility of dopaminergic depletion in the retina corresponding with basal ganglia dopamine depletion.https://www.nepjol.info/index.php/AJMS/article/view/45933optical coherence tomography; parkinson’s disease; retinal nerve fiber layer |
| spellingShingle | Bharat Vishnu Reddy Bindela Vamsavardhana Reddy Pidathala Kamalesh Tagadur Nataraju Assessment of severity of Parkinson’s disease by optical coherence tomography Asian Journal of Medical Sciences optical coherence tomography; parkinson’s disease; retinal nerve fiber layer |
| title | Assessment of severity of Parkinson’s disease by optical coherence tomography |
| title_full | Assessment of severity of Parkinson’s disease by optical coherence tomography |
| title_fullStr | Assessment of severity of Parkinson’s disease by optical coherence tomography |
| title_full_unstemmed | Assessment of severity of Parkinson’s disease by optical coherence tomography |
| title_short | Assessment of severity of Parkinson’s disease by optical coherence tomography |
| title_sort | assessment of severity of parkinson s disease by optical coherence tomography |
| topic | optical coherence tomography; parkinson’s disease; retinal nerve fiber layer |
| url | https://www.nepjol.info/index.php/AJMS/article/view/45933 |
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