Immunogenetic features of thyroid gland dysfunction combined with metabolic syndrome
A comparative analysis of the changes in the immune and genetic status in patients with metabolic syndrome (MetS) combined with thyroid pathology has been performed in comparison with patients only with MetS or thyroid gland (TG) dysfunction.Materials and methods: 90 patients were recruited and assi...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2018-03-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/2343 |
| _version_ | 1797841994450468864 |
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| author | A. A. Fateevа N. A. Martirosyan N. A. Petunina |
| author_facet | A. A. Fateevа N. A. Martirosyan N. A. Petunina |
| author_sort | A. A. Fateevа |
| collection | DOAJ |
| description | A comparative analysis of the changes in the immune and genetic status in patients with metabolic syndrome (MetS) combined with thyroid pathology has been performed in comparison with patients only with MetS or thyroid gland (TG) dysfunction.Materials and methods: 90 patients were recruited and assigned to one of three groups: A group of patients with MetS and TG dysfunction; a group of patients only with MetS; group of patients only with TG dysfunction. All patients underwent immune status assessment – CD3, CD4, CD8, CD16, CD4 +/CD8 +, and tumour necrosis factor (TNF) and C-reactive protein (CRP) levels were studied in a biochemical blood test. Genetic analysis consisted in determining the frequencies of alleles and genotypes of four polymorphic markers: rs10865710 of the PPARG3 gene, rs1042713 and rs1042711 of the ADRB2 gene and rs5443 of the GNB3 gene. Results: The combination of MetS with TG dysfunction regardless of the presence or absence of autoimmune thyroid diseases was characterized by aggravation of disorders in the Tand B-cell components of immune system, an increase in IgG, CRP, and TNF levels. Genetic analysis showed frequent detection of the A allele, the AA genotype of the polymorphic marker rs1042713 of the ADRB2 gene, coding β2-adrenoreceptor in the Kazakh population. |
| first_indexed | 2024-04-09T16:40:34Z |
| format | Article |
| id | doaj.art-ca1db1337554486fa0231caeec0bf234 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:40:34Z |
| publishDate | 2018-03-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-ca1db1337554486fa0231caeec0bf2342023-04-23T06:56:42ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902018-03-010411611910.21518/2079-701X-2018-4-116-1192319Immunogenetic features of thyroid gland dysfunction combined with metabolic syndromeA. A. Fateevа0N. A. Martirosyan1N. A. Petunina2Sechenov First Moscow State Medical University of the Ministry of Health of Russia; Asfendiyarov Kazakh National Medical UniversitySechenov First Moscow State Medical University of the Ministry of Health of RussiaSechenov First Moscow State Medical University of the Ministry of Health of RussiaA comparative analysis of the changes in the immune and genetic status in patients with metabolic syndrome (MetS) combined with thyroid pathology has been performed in comparison with patients only with MetS or thyroid gland (TG) dysfunction.Materials and methods: 90 patients were recruited and assigned to one of three groups: A group of patients with MetS and TG dysfunction; a group of patients only with MetS; group of patients only with TG dysfunction. All patients underwent immune status assessment – CD3, CD4, CD8, CD16, CD4 +/CD8 +, and tumour necrosis factor (TNF) and C-reactive protein (CRP) levels were studied in a biochemical blood test. Genetic analysis consisted in determining the frequencies of alleles and genotypes of four polymorphic markers: rs10865710 of the PPARG3 gene, rs1042713 and rs1042711 of the ADRB2 gene and rs5443 of the GNB3 gene. Results: The combination of MetS with TG dysfunction regardless of the presence or absence of autoimmune thyroid diseases was characterized by aggravation of disorders in the Tand B-cell components of immune system, an increase in IgG, CRP, and TNF levels. Genetic analysis showed frequent detection of the A allele, the AA genotype of the polymorphic marker rs1042713 of the ADRB2 gene, coding β2-adrenoreceptor in the Kazakh population.https://www.med-sovet.pro/jour/article/view/2343metabolic syndromethyroid gland dysfunctionimmune statuscardiovascular complications |
| spellingShingle | A. A. Fateevа N. A. Martirosyan N. A. Petunina Immunogenetic features of thyroid gland dysfunction combined with metabolic syndrome Медицинский совет metabolic syndrome thyroid gland dysfunction immune status cardiovascular complications |
| title | Immunogenetic features of thyroid gland dysfunction combined with metabolic syndrome |
| title_full | Immunogenetic features of thyroid gland dysfunction combined with metabolic syndrome |
| title_fullStr | Immunogenetic features of thyroid gland dysfunction combined with metabolic syndrome |
| title_full_unstemmed | Immunogenetic features of thyroid gland dysfunction combined with metabolic syndrome |
| title_short | Immunogenetic features of thyroid gland dysfunction combined with metabolic syndrome |
| title_sort | immunogenetic features of thyroid gland dysfunction combined with metabolic syndrome |
| topic | metabolic syndrome thyroid gland dysfunction immune status cardiovascular complications |
| url | https://www.med-sovet.pro/jour/article/view/2343 |
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