Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program
<p>Abstract</p> <p>Background</p> <p>Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting geno...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2006-03-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/7/17 |
| _version_ | 1811189351214743552 |
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| author | Ellison R Curtis Hunt Steven C Wilk Jemma B Laramie Jason M Chakravarti Aravinda Boerwinkle Eric Myers Richard H |
| author_facet | Ellison R Curtis Hunt Steven C Wilk Jemma B Laramie Jason M Chakravarti Aravinda Boerwinkle Eric Myers Richard H |
| author_sort | Ellison R Curtis |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic linkage scans to identify quantitative trait loci.</p> <p>Methods</p> <p>We performed a genome-wide linkage scan to identify quantitative trait loci influencing resting heart rate among 3,282 Caucasians and 3,989 African-Americans in three independent networks comprising the Family Blood Pressure Program (FBPP) using 368 microsatellite markers. Mean heart rate measurements were used in a regression model including covariates for age, body mass index, pack-years, currently drinking alcohol (yes/no), hypertension status and medication usage to create a standardized residual for each gender/ethnic group within each study network. This residual was used in a nonparametric variance component model to generate a LOD score and a corresponding P value for each ethnic group within each study network. P values from each ethnic group and study network were merged using an adjusted Fisher's combining P values method and the resulting P values were converted to LOD scores. The entire analysis was redone after individuals currently taking beta-blocker medication were removed.</p> <p>Results</p> <p>We identified significant evidence of linkage (LOD = 4.62) to chromosome 10 near 142.78 cM in the Caucasian group of HyperGEN. Between race and network groups we identified a LOD score of 1.86 on chromosome 5 (between 39.99 and 45.34 cM) in African-Americans in the GENOA network and the same region produced a LOD score of 1.12 among Caucasians within a different network (HyperGEN). Combining all network and race groups we identified a LOD score of 1.92 (<it>P </it>= 0.0013) on chromosome 5p13-14. We assessed heterogeneity for this locus between networks and ethnic groups and found significant evidence for low heterogeneity (<it>P </it>≤ 0.05).</p> <p>Conclusion</p> <p>We found replication (LOD > 1) between ethnic groups and between study networks with low heterogeneity on chromosome 5p13-14 suggesting that a gene in this region influences resting heart rate.</p> |
| first_indexed | 2024-04-11T14:33:30Z |
| format | Article |
| id | doaj.art-ca1dec530fde47a0aeaa3267c1eb1168 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-04-11T14:33:30Z |
| publishDate | 2006-03-01 |
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| series | BMC Medical Genetics |
| spelling | doaj.art-ca1dec530fde47a0aeaa3267c1eb11682022-12-22T04:18:26ZengBMCBMC Medical Genetics1471-23502006-03-01711710.1186/1471-2350-7-17Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure ProgramEllison R CurtisHunt Steven CWilk Jemma BLaramie Jason MChakravarti AravindaBoerwinkle EricMyers Richard H<p>Abstract</p> <p>Background</p> <p>Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic linkage scans to identify quantitative trait loci.</p> <p>Methods</p> <p>We performed a genome-wide linkage scan to identify quantitative trait loci influencing resting heart rate among 3,282 Caucasians and 3,989 African-Americans in three independent networks comprising the Family Blood Pressure Program (FBPP) using 368 microsatellite markers. Mean heart rate measurements were used in a regression model including covariates for age, body mass index, pack-years, currently drinking alcohol (yes/no), hypertension status and medication usage to create a standardized residual for each gender/ethnic group within each study network. This residual was used in a nonparametric variance component model to generate a LOD score and a corresponding P value for each ethnic group within each study network. P values from each ethnic group and study network were merged using an adjusted Fisher's combining P values method and the resulting P values were converted to LOD scores. The entire analysis was redone after individuals currently taking beta-blocker medication were removed.</p> <p>Results</p> <p>We identified significant evidence of linkage (LOD = 4.62) to chromosome 10 near 142.78 cM in the Caucasian group of HyperGEN. Between race and network groups we identified a LOD score of 1.86 on chromosome 5 (between 39.99 and 45.34 cM) in African-Americans in the GENOA network and the same region produced a LOD score of 1.12 among Caucasians within a different network (HyperGEN). Combining all network and race groups we identified a LOD score of 1.92 (<it>P </it>= 0.0013) on chromosome 5p13-14. We assessed heterogeneity for this locus between networks and ethnic groups and found significant evidence for low heterogeneity (<it>P </it>≤ 0.05).</p> <p>Conclusion</p> <p>We found replication (LOD > 1) between ethnic groups and between study networks with low heterogeneity on chromosome 5p13-14 suggesting that a gene in this region influences resting heart rate.</p>http://www.biomedcentral.com/1471-2350/7/17 |
| spellingShingle | Ellison R Curtis Hunt Steven C Wilk Jemma B Laramie Jason M Chakravarti Aravinda Boerwinkle Eric Myers Richard H Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program BMC Medical Genetics |
| title | Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program |
| title_full | Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program |
| title_fullStr | Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program |
| title_full_unstemmed | Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program |
| title_short | Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program |
| title_sort | evidence for a gene influencing heart rate on chromosome 5p13 14 in a meta analysis of genome wide scans from the nhlbi family blood pressure program |
| url | http://www.biomedcentral.com/1471-2350/7/17 |
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