A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis.

A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis.

There are no defined correlates of protection for any intracellular pathogen, including the bacterium Francisella tularensis, which causes tularemia. Evaluating vaccine efficacy against sporadic diseases like tularemia using field trials is problematic, and therefore alternative strategies to test v...

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Bibliographic Details
Main Authors: Roberto De Pascalis, Andrew Hahn, Helen M Brook, Patrik Ryden, Nathaniel Donart, Lara Mittereder, Blake Frey, Terry H Wu, Karen L Elkins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5969757?pdf=render

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