Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats
Neuroinflammation is considered a major factor in several neuropsychiatric disorders. Gypenosides (GPS) have pharmacological properties with multiple beneficial effects including antiinflammatory, antioxidative, and protective properties. The present study was performed to examine whether GPS shows...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-09-01
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| Series: | Animal Cells and Systems |
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| Online Access: | http://dx.doi.org/10.1080/19768354.2018.1517825 |
| _version_ | 1818496908260278272 |
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| author | Bombi Lee Insop Shim Hyejung Lee Dae-Hyun Hahm |
| author_facet | Bombi Lee Insop Shim Hyejung Lee Dae-Hyun Hahm |
| author_sort | Bombi Lee |
| collection | DOAJ |
| description | Neuroinflammation is considered a major factor in several neuropsychiatric disorders. Gypenosides (GPS) have pharmacological properties with multiple beneficial effects including antiinflammatory, antioxidative, and protective properties. The present study was performed to examine whether GPS shows anxiolytic-like effects in a model of chronic inflammation induced by injection of lipopolysaccharide (LPS) into the rat hippocampus. The effects of GPS on inflammatory factors in the hippocampus and the downstream mechanisms of these effects were also examined. Introduction of LPS into the lateral ventricle caused inflammatory reactions and anxiety-like symptoms in the rats. Daily treatment with GPS (25, 50, and 100 mg/kg) for 21 consecutive days significantly increased the time spent and number of visits to the open arm in the elevated plus maze test, and significantly increased the number of central zone crossings in the open field test. Moreover, GPS administration significantly reduced the freezing response to contextual fear conditioning, and significantly decreased the levels of proinflammatory mediators, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and nuclear factor-kappaB (NF-κB), levels in the brain. Furthermore, GPS reduced LPS-induced elevated levels of Toll-like receptor 4 (TLR4) mRNA and inhibition of brain-derived neurotrophic factor (BDNF) mRNA levels. Taken together, these results suggest that GPS may have anxiolytic-like effects and may have novel therapeutic potential for anxiety-like behaviors caused by neuroinflammation. GPS may be useful for developing an agents for the treatment of neuropsychiatric disorders, such as anxiety, due to its antiinflammatory activities and the modulation of NF-κB/iNOS/TLR4/BDNF. |
| first_indexed | 2024-12-10T18:38:31Z |
| format | Article |
| id | doaj.art-ca208c8d6efd4e56af969805c7b1b54f |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-12-10T18:38:31Z |
| publishDate | 2018-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-ca208c8d6efd4e56af969805c7b1b54f2022-12-22T01:37:44ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852018-09-0122530531610.1080/19768354.2018.15178251517825Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in ratsBombi Lee0Insop Shim1Hyejung Lee2Dae-Hyun Hahm3Kyung Hee UniversityKyung Hee UniversityKyung Hee UniversityKyung Hee UniversityNeuroinflammation is considered a major factor in several neuropsychiatric disorders. Gypenosides (GPS) have pharmacological properties with multiple beneficial effects including antiinflammatory, antioxidative, and protective properties. The present study was performed to examine whether GPS shows anxiolytic-like effects in a model of chronic inflammation induced by injection of lipopolysaccharide (LPS) into the rat hippocampus. The effects of GPS on inflammatory factors in the hippocampus and the downstream mechanisms of these effects were also examined. Introduction of LPS into the lateral ventricle caused inflammatory reactions and anxiety-like symptoms in the rats. Daily treatment with GPS (25, 50, and 100 mg/kg) for 21 consecutive days significantly increased the time spent and number of visits to the open arm in the elevated plus maze test, and significantly increased the number of central zone crossings in the open field test. Moreover, GPS administration significantly reduced the freezing response to contextual fear conditioning, and significantly decreased the levels of proinflammatory mediators, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and nuclear factor-kappaB (NF-κB), levels in the brain. Furthermore, GPS reduced LPS-induced elevated levels of Toll-like receptor 4 (TLR4) mRNA and inhibition of brain-derived neurotrophic factor (BDNF) mRNA levels. Taken together, these results suggest that GPS may have anxiolytic-like effects and may have novel therapeutic potential for anxiety-like behaviors caused by neuroinflammation. GPS may be useful for developing an agents for the treatment of neuropsychiatric disorders, such as anxiety, due to its antiinflammatory activities and the modulation of NF-κB/iNOS/TLR4/BDNF.http://dx.doi.org/10.1080/19768354.2018.1517825Anxietygypenosidesinflammationlipopolysaccharidenuclear factor-kappaB |
| spellingShingle | Bombi Lee Insop Shim Hyejung Lee Dae-Hyun Hahm Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats Animal Cells and Systems Anxiety gypenosides inflammation lipopolysaccharide nuclear factor-kappaB |
| title | Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats |
| title_full | Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats |
| title_fullStr | Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats |
| title_full_unstemmed | Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats |
| title_short | Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats |
| title_sort | gypenosides attenuate lipopolysaccharide induced neuroinflammation and anxiety like behaviors in rats |
| topic | Anxiety gypenosides inflammation lipopolysaccharide nuclear factor-kappaB |
| url | http://dx.doi.org/10.1080/19768354.2018.1517825 |
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