Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs

Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs

The tumor microenvironment plays important roles in cancer biology, but genetic backgrounds of mouse models can complicate interpretation of tumor phenotypes. A deeper understanding of strain-dependent influences on the tumor microenvironment of genetically-identical tumors is critical to exploring...

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Bibliographic Details
Main Authors: Amanda Scherer, Victoria R. Stephens, Gavin R. McGivney, Wade R. Gutierrez, Emily A. Laverty, Vickie Knepper-Adrian, Rebecca D. Dodd
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Genes
Subjects:
CRISPR/Cas9
MPNST
mouse models
sarcoma
tumor microenvironment
Online Access:https://www.mdpi.com/2073-4425/11/5/583

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