CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus
Women with diabetes mellitus are believed to have increased risk of developing breast cancer and lower life expectancies. This study aims to depict the association between the CISD1, the co-expressed genes, and diabetes mellitus to offer potential therapeutic targets for further mechanical research....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/1/37 |
| _version_ | 1797445564108898304 |
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| author | Fangfang Liu Yifeng Dong Fuyu Zhong Haodan Guo Pengzhi Dong |
| author_facet | Fangfang Liu Yifeng Dong Fuyu Zhong Haodan Guo Pengzhi Dong |
| author_sort | Fangfang Liu |
| collection | DOAJ |
| description | Women with diabetes mellitus are believed to have increased risk of developing breast cancer and lower life expectancies. This study aims to depict the association between the CISD1, the co-expressed genes, and diabetes mellitus to offer potential therapeutic targets for further mechanical research. The TCGA-BRCA RNAseq data is acquired. All the data and analyzed using R packages and web-based bioinformatics tools. CISD1 gene expression was evaluated between tumor bulk and adjacent tissue. Immune cell infiltration evaluation was performed. CISD1 expressed significantly higher in tumor tissue than that of the normal tissue, indicating poor overall survival rates. High expression level of CISD1 in tumor shows less pDC and NK cells penetration. There are 138 genes shared between CISD1 co-expressed gene pool in BRCA and diabetes mellitus related genes using “diabetes” as the term for text mining. These shared genes enrich in “cell cycle” and other pathways. MCODE analysis demonstrates that p53-independent G1/S DNA damage checkpoint, p53-independent DNA damage response, and ubiquitin mediated degradation of phosphorylated cdc25A are top-ranked than other terms. CISD1 and co-expressed genes, especially shared ones with diabetes mellitus, can be the focused genes considered when addressing clinical problems in breast cancer with a diabetes mellitus background. |
| first_indexed | 2024-03-09T13:27:37Z |
| format | Article |
| id | doaj.art-ca22a5c543cd4e32ae29029bbc875fc9 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:27:37Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ca22a5c543cd4e32ae29029bbc875fc92023-11-30T21:21:51ZengMDPI AGBiomolecules2218-273X2022-12-011313710.3390/biom13010037CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes MellitusFangfang Liu0Yifeng Dong1Fuyu Zhong2Haodan Guo3Pengzhi Dong4Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, ChinaWomen with diabetes mellitus are believed to have increased risk of developing breast cancer and lower life expectancies. This study aims to depict the association between the CISD1, the co-expressed genes, and diabetes mellitus to offer potential therapeutic targets for further mechanical research. The TCGA-BRCA RNAseq data is acquired. All the data and analyzed using R packages and web-based bioinformatics tools. CISD1 gene expression was evaluated between tumor bulk and adjacent tissue. Immune cell infiltration evaluation was performed. CISD1 expressed significantly higher in tumor tissue than that of the normal tissue, indicating poor overall survival rates. High expression level of CISD1 in tumor shows less pDC and NK cells penetration. There are 138 genes shared between CISD1 co-expressed gene pool in BRCA and diabetes mellitus related genes using “diabetes” as the term for text mining. These shared genes enrich in “cell cycle” and other pathways. MCODE analysis demonstrates that p53-independent G1/S DNA damage checkpoint, p53-independent DNA damage response, and ubiquitin mediated degradation of phosphorylated cdc25A are top-ranked than other terms. CISD1 and co-expressed genes, especially shared ones with diabetes mellitus, can be the focused genes considered when addressing clinical problems in breast cancer with a diabetes mellitus background.https://www.mdpi.com/2218-273X/13/1/37CISD1breast cancerdiabetes mellitusbioinformaticsferroptosis |
| spellingShingle | Fangfang Liu Yifeng Dong Fuyu Zhong Haodan Guo Pengzhi Dong CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus Biomolecules CISD1 breast cancer diabetes mellitus bioinformatics ferroptosis |
| title | CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus |
| title_full | CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus |
| title_fullStr | CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus |
| title_full_unstemmed | CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus |
| title_short | CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus |
| title_sort | cisd1 is a breast cancer prognostic biomarker associated with diabetes mellitus |
| topic | CISD1 breast cancer diabetes mellitus bioinformatics ferroptosis |
| url | https://www.mdpi.com/2218-273X/13/1/37 |
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