NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE
A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric am...
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2018-04-01
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| Series: | Eclética Química |
| Online Access: | https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/211 |
| _version_ | 1818575414596993024 |
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| author | Badiadka Narayana K. Veena K. Ashwani Divya N. Shetty |
| author_facet | Badiadka Narayana K. Veena K. Ashwani Divya N. Shetty |
| author_sort | Badiadka Narayana |
| collection | DOAJ |
| description | A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer’s law is obeyed in the concentration range of 0.4-8.0 μg/ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6μg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell’s sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms. |
| first_indexed | 2024-12-15T00:39:58Z |
| format | Article |
| id | doaj.art-ca249db8f4634dbcaf7722fa35e66dfa |
| institution | Directory Open Access Journal |
| issn | 1678-4618 |
| language | English |
| last_indexed | 2024-12-15T00:39:58Z |
| publishDate | 2018-04-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Eclética Química |
| spelling | doaj.art-ca249db8f4634dbcaf7722fa35e66dfa2022-12-21T22:41:41ZengUniversidade Estadual PaulistaEclética Química1678-46182018-04-0135310911510.26850/1678-4618eqj.v35.3.2010.p109-115211NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDEBadiadka Narayana0K. Veena1K. Ashwani2Divya N. Shetty3Department of P.G. Studies and Research in Chemistry, Mangalore UniversityDepartment of P.G. Studies and Research in Chemistry, Mangalore UniversityDepartment of P.G. Studies and Research in Chemistry, Mangalore UniversityDepartment of P.G. Studies and Research in Chemistry, Mangalore UniversityA new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer’s law is obeyed in the concentration range of 0.4-8.0 μg/ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6μg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell’s sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms.https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/211 |
| spellingShingle | Badiadka Narayana K. Veena K. Ashwani Divya N. Shetty NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE Eclética Química |
| title | NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE |
| title_full | NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE |
| title_fullStr | NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE |
| title_full_unstemmed | NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE |
| title_short | NEW REAGENTS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE |
| title_sort | new reagents for the spectrophotometric determination of ranitidine hydrochloride |
| url | https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/211 |
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