Long-Term Outcomes among Patients with Prolonged Disorders of Consciousness
Purpose: To evaluate the long-term survival and functional outcomes of patients with prolonged disorders of consciousness (pDoC) 1–8 years after brain injuries. Methods: Retrospective study to assess the long-term survival and functional outcomes of patients with pDoC was conducted. We performed Cox...
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MDPI AG
2023-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/2/194 |
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| author | Yan Liu Xiao-Gang Kang Qiong Gao Yu Liu Chang-Geng Song Xiao-Jing Shi Jia-Ning Wu Wen Jiang |
| author_facet | Yan Liu Xiao-Gang Kang Qiong Gao Yu Liu Chang-Geng Song Xiao-Jing Shi Jia-Ning Wu Wen Jiang |
| author_sort | Yan Liu |
| collection | DOAJ |
| description | Purpose: To evaluate the long-term survival and functional outcomes of patients with prolonged disorders of consciousness (pDoC) 1–8 years after brain injuries. Methods: Retrospective study to assess the long-term survival and functional outcomes of patients with pDoC was conducted. We performed Cox regression and multivariate logistic regression to calculate hazard ratios (HRs) for the outcome of survival and to identify risk factors of the functional outcome. Results: We recruited 154 patients with pDoC. The duration of follow-up from disease onset was 1–8 years. The median age was 46 years (IQR, 32–59), and 65.6% (<i>n</i> = 101) of them were men. During the follow-up period, one hundred and ten patients (71.4%) survived; among them, 52 patients had a good outcome. From the overall survival curve, the 1-, 3-, and 8-year survival rates of patients were about 80.5%, 72.0%, and 69.7%, respectively. Cox regression analysis revealed a significant association between the lower APACHE II score (<i>p</i> = 0.005) (cut-off score ≥ 18) and the presence of sleep spindles (<i>p</i> = 0.001) with survival. Logistic regression analysis demonstrated a higher CRS-R score (cut-off score ≥ 7), and presence of sleep spindles were related to a favorable outcome among patients with pDoC. Conclusions: Sleep spindles are correlated with both long-term survival and long-term functional outcome in pDoC patients. |
| first_indexed | 2024-03-11T09:05:20Z |
| format | Article |
| id | doaj.art-ca24b1bf845e4b3c95a68b5613218e87 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T09:05:20Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-ca24b1bf845e4b3c95a68b5613218e872023-11-16T19:27:32ZengMDPI AGBrain Sciences2076-34252023-01-0113219410.3390/brainsci13020194Long-Term Outcomes among Patients with Prolonged Disorders of ConsciousnessYan Liu0Xiao-Gang Kang1Qiong Gao2Yu Liu3Chang-Geng Song4Xiao-Jing Shi5Jia-Ning Wu6Wen Jiang7Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaPurpose: To evaluate the long-term survival and functional outcomes of patients with prolonged disorders of consciousness (pDoC) 1–8 years after brain injuries. Methods: Retrospective study to assess the long-term survival and functional outcomes of patients with pDoC was conducted. We performed Cox regression and multivariate logistic regression to calculate hazard ratios (HRs) for the outcome of survival and to identify risk factors of the functional outcome. Results: We recruited 154 patients with pDoC. The duration of follow-up from disease onset was 1–8 years. The median age was 46 years (IQR, 32–59), and 65.6% (<i>n</i> = 101) of them were men. During the follow-up period, one hundred and ten patients (71.4%) survived; among them, 52 patients had a good outcome. From the overall survival curve, the 1-, 3-, and 8-year survival rates of patients were about 80.5%, 72.0%, and 69.7%, respectively. Cox regression analysis revealed a significant association between the lower APACHE II score (<i>p</i> = 0.005) (cut-off score ≥ 18) and the presence of sleep spindles (<i>p</i> = 0.001) with survival. Logistic regression analysis demonstrated a higher CRS-R score (cut-off score ≥ 7), and presence of sleep spindles were related to a favorable outcome among patients with pDoC. Conclusions: Sleep spindles are correlated with both long-term survival and long-term functional outcome in pDoC patients.https://www.mdpi.com/2076-3425/13/2/194disorders of consciousnessunresponsive wakefulness syndromeminimal consciousness statemortalityprognostic |
| spellingShingle | Yan Liu Xiao-Gang Kang Qiong Gao Yu Liu Chang-Geng Song Xiao-Jing Shi Jia-Ning Wu Wen Jiang Long-Term Outcomes among Patients with Prolonged Disorders of Consciousness Brain Sciences disorders of consciousness unresponsive wakefulness syndrome minimal consciousness state mortality prognostic |
| title | Long-Term Outcomes among Patients with Prolonged Disorders of Consciousness |
| title_full | Long-Term Outcomes among Patients with Prolonged Disorders of Consciousness |
| title_fullStr | Long-Term Outcomes among Patients with Prolonged Disorders of Consciousness |
| title_full_unstemmed | Long-Term Outcomes among Patients with Prolonged Disorders of Consciousness |
| title_short | Long-Term Outcomes among Patients with Prolonged Disorders of Consciousness |
| title_sort | long term outcomes among patients with prolonged disorders of consciousness |
| topic | disorders of consciousness unresponsive wakefulness syndrome minimal consciousness state mortality prognostic |
| url | https://www.mdpi.com/2076-3425/13/2/194 |
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