Effect of MoS2-PEG nanozymes on tumor cell multiplication
Molybdenum disulfide (MoS2), as a nanozyme, can effectively kill tumor cells by catalyzing H2O2 to produce extremely poisonous hydroxyl radical (*OH). In this work, spherical MoS2-PEG nanozymes were prepared by hydrothermal synthesis under the modification of polyethylene glycol (PEG). Firstly, XRD,...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-11-01
|
| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223007025 |
| _version_ | 1827791751860977664 |
|---|---|
| author | Zuoda Liu Yuan Gao Lianpu Wen Xue Wang Jianmin Feng Changjun Zhu Dejun Li Mengli Zhao |
| author_facet | Zuoda Liu Yuan Gao Lianpu Wen Xue Wang Jianmin Feng Changjun Zhu Dejun Li Mengli Zhao |
| author_sort | Zuoda Liu |
| collection | DOAJ |
| description | Molybdenum disulfide (MoS2), as a nanozyme, can effectively kill tumor cells by catalyzing H2O2 to produce extremely poisonous hydroxyl radical (*OH). In this work, spherical MoS2-PEG nanozymes were prepared by hydrothermal synthesis under the modification of polyethylene glycol (PEG). Firstly, XRD, XPS, SEM, TEM, and BET were used to analyze the phase, morphology, oxidation state, and distribution of each element of nanozyme. Secondly, the determination and verification of *OH as the main reactive oxygen species (ROS) in the MoS2-PEG nanozyme catalyzed Fenton reaction based on 3,3′,5,5′-tetramethyldiphenylamine (TMB) color reaction and electron spin resonance (ESR). Interestingly, MoS2-PEG nanozymes exhibited cytostatic rates of 43.9 % and 47.2 % in vitro in mouse breast cancer cell (4 T1) and mouse glioma cell (GL261) tumor cell models. In mouse fibroblast (L929) models, MoS2-PEG nanozymes showed excellent cytocompatibility and safety. Therefore, MoS2-PEG nanozyme may serve as an impactful drug to inhibit cancer cell growth. |
| first_indexed | 2024-03-11T17:51:20Z |
| format | Article |
| id | doaj.art-ca259077c253420988632275aacfe462 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-03-11T17:51:20Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-ca259077c253420988632275aacfe4622023-10-18T04:30:41ZengElsevierArabian Journal of Chemistry1878-53522023-11-011611105240Effect of MoS2-PEG nanozymes on tumor cell multiplicationZuoda Liu0Yuan Gao1Lianpu Wen2Xue Wang3Jianmin Feng4Changjun Zhu5Dejun Li6Mengli Zhao7College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, ChinaCollege of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, ChinaCollege of Life Science, Tianjin Normal University, Tianjin 300387, ChinaCollege of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, ChinaCollege of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, ChinaCollege of Life Science, Tianjin Normal University, Tianjin 300387, ChinaCollege of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, China; Corresponding authors at: 393#, Binshuixi Road, Xiqing District, Tianjin 300387, China.School of Electronic Engineering, Chaohu University, Anhui 238024, China; Corresponding authors at: 393#, Binshuixi Road, Xiqing District, Tianjin 300387, China.Molybdenum disulfide (MoS2), as a nanozyme, can effectively kill tumor cells by catalyzing H2O2 to produce extremely poisonous hydroxyl radical (*OH). In this work, spherical MoS2-PEG nanozymes were prepared by hydrothermal synthesis under the modification of polyethylene glycol (PEG). Firstly, XRD, XPS, SEM, TEM, and BET were used to analyze the phase, morphology, oxidation state, and distribution of each element of nanozyme. Secondly, the determination and verification of *OH as the main reactive oxygen species (ROS) in the MoS2-PEG nanozyme catalyzed Fenton reaction based on 3,3′,5,5′-tetramethyldiphenylamine (TMB) color reaction and electron spin resonance (ESR). Interestingly, MoS2-PEG nanozymes exhibited cytostatic rates of 43.9 % and 47.2 % in vitro in mouse breast cancer cell (4 T1) and mouse glioma cell (GL261) tumor cell models. In mouse fibroblast (L929) models, MoS2-PEG nanozymes showed excellent cytocompatibility and safety. Therefore, MoS2-PEG nanozyme may serve as an impactful drug to inhibit cancer cell growth.http://www.sciencedirect.com/science/article/pii/S1878535223007025MoS2-PEG nanozymesFenton reactionsInhibit tumorHydrothermal synthesis |
| spellingShingle | Zuoda Liu Yuan Gao Lianpu Wen Xue Wang Jianmin Feng Changjun Zhu Dejun Li Mengli Zhao Effect of MoS2-PEG nanozymes on tumor cell multiplication Arabian Journal of Chemistry MoS2-PEG nanozymes Fenton reactions Inhibit tumor Hydrothermal synthesis |
| title | Effect of MoS2-PEG nanozymes on tumor cell multiplication |
| title_full | Effect of MoS2-PEG nanozymes on tumor cell multiplication |
| title_fullStr | Effect of MoS2-PEG nanozymes on tumor cell multiplication |
| title_full_unstemmed | Effect of MoS2-PEG nanozymes on tumor cell multiplication |
| title_short | Effect of MoS2-PEG nanozymes on tumor cell multiplication |
| title_sort | effect of mos2 peg nanozymes on tumor cell multiplication |
| topic | MoS2-PEG nanozymes Fenton reactions Inhibit tumor Hydrothermal synthesis |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223007025 |
| work_keys_str_mv | AT zuodaliu effectofmos2pegnanozymesontumorcellmultiplication AT yuangao effectofmos2pegnanozymesontumorcellmultiplication AT lianpuwen effectofmos2pegnanozymesontumorcellmultiplication AT xuewang effectofmos2pegnanozymesontumorcellmultiplication AT jianminfeng effectofmos2pegnanozymesontumorcellmultiplication AT changjunzhu effectofmos2pegnanozymesontumorcellmultiplication AT dejunli effectofmos2pegnanozymesontumorcellmultiplication AT menglizhao effectofmos2pegnanozymesontumorcellmultiplication |