| Summary: | This study aims to optimize ultrasonic-assisted natural deep eutectic solvents (NADES) based extraction from <i>C. longa</i>. Choline chloride-lactic acid (CCLA-H<sub>2</sub>O = 1:1, b/v) was used to investigate the impact of various process parameters such as solvent’s water content, solid loading, temperature, and extraction time. The optimal yield of 79.635 mg/g of <i>C. longa</i> was achieved from extraction in 20% water content NADES with a 4% solid loading in 35 °C temperature for 1 h. Peleg’s model was used to describe the kinetics of the optimized ultrasonic-assisted extraction (UAE) method, and the results were found to be compatible with experimental data. The optimum conditions obtained from <i>C. longa</i> extraction were then used for the extraction of <i>C. xanthorriza</i> and <i>C. mangga</i>, which give yields of 2.056 and 31.322 mg/g, respectively. Furthermore, n-hexane was utilized as an anti-solvent in the separation process of curcuminoids extract from <i>C. longa</i>, <i>C. xanthorriza</i>, and <i>C. mangga</i>, which gave curcuminoid recovery of 39%, 0.74%, and 27%, respectively. Solidification of curcuminoids was also carried out using the crystallization method with n-hexane and isopropanol. However, the solution of CCLA and curcuminoids formed a homogeneous mixture with isopropanol. Hence, the curcuminoids could not be solidified due to the presence of NADES in the extract solution.
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