Research progress on the role of ADAM17 in the pathogenesis of atherosclerosis
Atherosclerosis is a kind of chronic inflammatory disease involving imbalance of lipid metabolism and immune disorders. The disintegrin metalloprotease 17(ADAM17) is a classic membrane protein shedding enzyme, which promotes atherosclerosis by participating in the process of inflammatory response, a...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-05-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201126.pdf |
| Summary: | Atherosclerosis is a kind of chronic inflammatory disease involving imbalance of lipid metabolism and immune disorders. The disintegrin metalloprotease 17(ADAM17) is a classic membrane protein shedding enzyme, which promotes atherosclerosis by participating in the process of inflammatory response, angiogenesis and plaque instability. In a few cases, ADAM17 also exhibits anti-atherosclerotic effects. Therefore, paying attention to the mechanism of ADAM17 in atherosclerosis will help to provide new insights into the diagnosis and treatment of atherosclerosis. |
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| ISSN: | 1001-6325 |