The effect of Nitroprusside on the renal ischaemia-reperfusion injury
Nitric oxide (NO) is implicated as an important mediator of, or intermediary in, inflammation, immunity and neurotransmission. In the kidney, No is involved in haemodynamic regulation, control of vascular tone and tubular function. Formation of oxygen-derived free radicals (OFR) have been documented...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2002-05-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/1070.pdf&manuscript_id=1070 |
| _version_ | 1818808337159946240 |
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| author | Kadkhodaee M Hanson GR Willgoss DA Gobe GC Endre ZH |
| author_facet | Kadkhodaee M Hanson GR Willgoss DA Gobe GC Endre ZH |
| author_sort | Kadkhodaee M |
| collection | DOAJ |
| description | Nitric oxide (NO) is implicated as an important mediator of, or intermediary in, inflammation, immunity and neurotransmission. In the kidney, No is involved in haemodynamic regulation, control of vascular tone and tubular function. Formation of oxygen-derived free radicals (OFR) have been documented in renal ischaemia- reperfusion before. In this study , we investigated the significance of No formation, by the addition of nitroprusside (0.2 mm) as an No donor, in the ischaemia- reperfused (IR) kidneys. Induction of Ir significantly reduced renal function compared to controls. In this study, nitroprusside showed beneficial effects on renal morphology although did not alter function over a short period of time. |
| first_indexed | 2024-12-18T19:39:57Z |
| format | Article |
| id | doaj.art-ca26eaa8c16d4f219afb5bd7926a7999 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 |
| language | English |
| last_indexed | 2024-12-18T19:39:57Z |
| publishDate | 2002-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-ca26eaa8c16d4f219afb5bd7926a79992022-12-21T20:55:29ZengTehran University of Medical SciencesActa Medica Iranica0044-60252002-05-014016064The effect of Nitroprusside on the renal ischaemia-reperfusion injuryKadkhodaee MHanson GRWillgoss DAGobe GCEndre ZHNitric oxide (NO) is implicated as an important mediator of, or intermediary in, inflammation, immunity and neurotransmission. In the kidney, No is involved in haemodynamic regulation, control of vascular tone and tubular function. Formation of oxygen-derived free radicals (OFR) have been documented in renal ischaemia- reperfusion before. In this study , we investigated the significance of No formation, by the addition of nitroprusside (0.2 mm) as an No donor, in the ischaemia- reperfused (IR) kidneys. Induction of Ir significantly reduced renal function compared to controls. In this study, nitroprusside showed beneficial effects on renal morphology although did not alter function over a short period of time.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/1070.pdf&manuscript_id=1070NitroprussideIschaemia-reperfusion |
| spellingShingle | Kadkhodaee M Hanson GR Willgoss DA Gobe GC Endre ZH The effect of Nitroprusside on the renal ischaemia-reperfusion injury Acta Medica Iranica Nitroprusside Ischaemia-reperfusion |
| title | The effect of Nitroprusside on the renal ischaemia-reperfusion injury |
| title_full | The effect of Nitroprusside on the renal ischaemia-reperfusion injury |
| title_fullStr | The effect of Nitroprusside on the renal ischaemia-reperfusion injury |
| title_full_unstemmed | The effect of Nitroprusside on the renal ischaemia-reperfusion injury |
| title_short | The effect of Nitroprusside on the renal ischaemia-reperfusion injury |
| title_sort | effect of nitroprusside on the renal ischaemia reperfusion injury |
| topic | Nitroprusside Ischaemia-reperfusion |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/1070.pdf&manuscript_id=1070 |
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