Assessment of a Model-Informed Precision Dosing Platform Use in Routine Clinical Care for Personalized Busulfan Therapy in the Pediatric Hematopoietic Cell Transplantation (HCT) Population

Assessment of a Model-Informed Precision Dosing Platform Use in Routine Clinical Care for Personalized Busulfan Therapy in the Pediatric Hematopoietic Cell Transplantation (HCT) Population

IntroductionPopulation pharmacokinetic (PK) studies demonstrate model-based dosing for busulfan that incorporates body size and age improve clinical target attainment as compared to weight-based regimens. Recently, for clinical dosing of busulfan and TDM, our institution transitioned to a cloud-base...

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Bibliographic Details
Main Authors: Praveen Shukla, Srijib Goswami, Ron J. Keizer, Beth Apsel Winger, Sandhya Kharbanda, Christopher C. Dvorak, Janel Long-Boyle
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
busulfan
pharmacokinetics
pediatric
therapeutic drug monitoring
hematopoietic cell transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00888/full

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