Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study
Autism spectrum disorders (ASDs) and functional neurological disorders (FNDs) share some clinical characteristics such as alexithymia, sensory sensitivity and interoceptive issues. Recent evidence shows that both the disorders present symptoms compatible with a diagnosis of hypermobile Ehlers-Danlos...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.943098/full |
| _version_ | 1818513251848159232 |
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| author | Veronica Nisticò Veronica Nisticò Veronica Nisticò Adriano Iacono Diana Goeta Roberta Tedesco Barbara Giordano Raffaella Faggioli Alberto Priori Alberto Priori Alberto Priori Orsola Gambini Orsola Gambini Orsola Gambini Benedetta Demartini Benedetta Demartini Benedetta Demartini |
| author_facet | Veronica Nisticò Veronica Nisticò Veronica Nisticò Adriano Iacono Diana Goeta Roberta Tedesco Barbara Giordano Raffaella Faggioli Alberto Priori Alberto Priori Alberto Priori Orsola Gambini Orsola Gambini Orsola Gambini Benedetta Demartini Benedetta Demartini Benedetta Demartini |
| author_sort | Veronica Nisticò |
| collection | DOAJ |
| description | Autism spectrum disorders (ASDs) and functional neurological disorders (FNDs) share some clinical characteristics such as alexithymia, sensory sensitivity and interoceptive issues. Recent evidence shows that both the disorders present symptoms compatible with a diagnosis of hypermobile Ehlers-Danlos Syndrome and hypermobile spectrum disorders (hEDS/HSD), a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Here we compared the prevalence of hEDS/HSD-related symptoms in a group of patients with FNDs, of people with ASDs without intellectual disabilities, and a non-clinical comparison group (NC). Twenty patients with FNDs, 27 individuals with ASDs without intellectual disabilities and 26 NC were recruited and completed the Self-reported screening questionnaire for the assessment of hEDS/HSD-related symptoms (SQ-CH). We found that 55% of the patients with FNDs, 44.4% of the individuals with ASDs and 30.8% of NC scored above the cut-off at the SQ-CH; SQ-CH scores of both FNDs and ASDs group were significantly higher than the NC group's ones. In conclusion, both ASDs and FNDs individuals present hEDS/HSD-related symptoms in a higher number than the general population. Imputable mechanisms include (i) overwhelming of executive functions with consequent motor competence impairment for ASDs individuals, and (ii) exacerbation of FNDs symptoms by physical injury and chronic pain due to abnormal range of joint mobility. Moreover, we speculated that the amygdala and the anterior cingulate cortex circuitry might be responsible for the imbalances at the proprioceptive, interoceptive, and emotional levels. |
| first_indexed | 2024-12-10T23:58:40Z |
| format | Article |
| id | doaj.art-ca27dfbbfe114504bf259171ea2dca35 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-10T23:58:40Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-ca27dfbbfe114504bf259171ea2dca352022-12-22T01:28:32ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-08-011310.3389/fpsyt.2022.943098943098Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary studyVeronica Nisticò0Veronica Nisticò1Veronica Nisticò2Adriano Iacono3Diana Goeta4Roberta Tedesco5Barbara Giordano6Raffaella Faggioli7Alberto Priori8Alberto Priori9Alberto Priori10Orsola Gambini11Orsola Gambini12Orsola Gambini13Benedetta Demartini14Benedetta Demartini15Benedetta Demartini16Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy“Aldo Ravelli” Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan, Milan, ItalyDipartimento di Psicologia, Università degli Studi di Milano-Bicocca, Milan, ItalyDipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, ItalyUnità di Psichiatria, Presidio San Carlo, Azienda Socio-Sanitaria Territoriale (ASST) Santi Paolo e Carlo, Milan, ItalyDipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, ItalyUnità di Psichiatria 52, Presidio San Paolo, Azienda Socio-Sanitaria Territoriale (ASST) Santi Paolo e Carlo, Milan, ItalyUnità di Psichiatria 52, Presidio San Paolo, Azienda Socio-Sanitaria Territoriale (ASST) Santi Paolo e Carlo, Milan, ItalyDipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy“Aldo Ravelli” Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan, Milan, ItalyIII Clinica Neurologica, Presidio San Paolo, Azienda Socio-Sanitaria Territoriale (ASST) Santi Paolo e Carlo, Milan, ItalyDipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy“Aldo Ravelli” Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan, Milan, ItalyUnità di Psichiatria 52, Presidio San Paolo, Azienda Socio-Sanitaria Territoriale (ASST) Santi Paolo e Carlo, Milan, ItalyDipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy“Aldo Ravelli” Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan, Milan, ItalyUnità di Psichiatria 52, Presidio San Paolo, Azienda Socio-Sanitaria Territoriale (ASST) Santi Paolo e Carlo, Milan, ItalyAutism spectrum disorders (ASDs) and functional neurological disorders (FNDs) share some clinical characteristics such as alexithymia, sensory sensitivity and interoceptive issues. Recent evidence shows that both the disorders present symptoms compatible with a diagnosis of hypermobile Ehlers-Danlos Syndrome and hypermobile spectrum disorders (hEDS/HSD), a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Here we compared the prevalence of hEDS/HSD-related symptoms in a group of patients with FNDs, of people with ASDs without intellectual disabilities, and a non-clinical comparison group (NC). Twenty patients with FNDs, 27 individuals with ASDs without intellectual disabilities and 26 NC were recruited and completed the Self-reported screening questionnaire for the assessment of hEDS/HSD-related symptoms (SQ-CH). We found that 55% of the patients with FNDs, 44.4% of the individuals with ASDs and 30.8% of NC scored above the cut-off at the SQ-CH; SQ-CH scores of both FNDs and ASDs group were significantly higher than the NC group's ones. In conclusion, both ASDs and FNDs individuals present hEDS/HSD-related symptoms in a higher number than the general population. Imputable mechanisms include (i) overwhelming of executive functions with consequent motor competence impairment for ASDs individuals, and (ii) exacerbation of FNDs symptoms by physical injury and chronic pain due to abnormal range of joint mobility. Moreover, we speculated that the amygdala and the anterior cingulate cortex circuitry might be responsible for the imbalances at the proprioceptive, interoceptive, and emotional levels.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.943098/fullautism spectrum disordersfunctional neurological disordersconversion disorderJoint Hypermobility SyndromeEhlers-Danlos Syndromeconnective tissue disorder |
| spellingShingle | Veronica Nisticò Veronica Nisticò Veronica Nisticò Adriano Iacono Diana Goeta Roberta Tedesco Barbara Giordano Raffaella Faggioli Alberto Priori Alberto Priori Alberto Priori Orsola Gambini Orsola Gambini Orsola Gambini Benedetta Demartini Benedetta Demartini Benedetta Demartini Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study Frontiers in Psychiatry autism spectrum disorders functional neurological disorders conversion disorder Joint Hypermobility Syndrome Ehlers-Danlos Syndrome connective tissue disorder |
| title | Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study |
| title_full | Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study |
| title_fullStr | Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study |
| title_full_unstemmed | Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study |
| title_short | Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study |
| title_sort | hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders a preliminary study |
| topic | autism spectrum disorders functional neurological disorders conversion disorder Joint Hypermobility Syndrome Ehlers-Danlos Syndrome connective tissue disorder |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.943098/full |
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