Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first fu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full |
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| author | Jie-Yu Chuang Cindy C. Hagan Cindy C. Hagan Cindy C. Hagan Graham K. Murray Graham K. Murray Graham K. Murray Julia M. E. Graham Cinly Ooi Roger Tait Rosemary J. Holt Rebecca Elliott Adrienne O. van Nieuwenhuizen Edward T. Bullmore Belinda R. Lennox Barbara J. Sahakian Barbara J. Sahakian Ian M. Goodyer John Suckling John Suckling John Suckling |
| author_facet | Jie-Yu Chuang Cindy C. Hagan Cindy C. Hagan Cindy C. Hagan Graham K. Murray Graham K. Murray Graham K. Murray Julia M. E. Graham Cinly Ooi Roger Tait Rosemary J. Holt Rebecca Elliott Adrienne O. van Nieuwenhuizen Edward T. Bullmore Belinda R. Lennox Barbara J. Sahakian Barbara J. Sahakian Ian M. Goodyer John Suckling John Suckling John Suckling |
| author_sort | Jie-Yu Chuang |
| collection | DOAJ |
| description | Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD. |
| first_indexed | 2024-12-22T08:02:49Z |
| format | Article |
| id | doaj.art-ca283673a5944a61afb1878adeba006b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T08:02:49Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-ca283673a5944a61afb1878adeba006b2022-12-21T18:33:13ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402017-07-01810.3389/fpsyt.2017.00119265234Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go TaskJie-Yu Chuang0Cindy C. Hagan1Cindy C. Hagan2Cindy C. Hagan3Graham K. Murray4Graham K. Murray5Graham K. Murray6Julia M. E. Graham7Cinly Ooi8Roger Tait9Rosemary J. Holt10Rebecca Elliott11Adrienne O. van Nieuwenhuizen12Edward T. Bullmore13Belinda R. Lennox14Barbara J. Sahakian15Barbara J. Sahakian16Ian M. Goodyer17John Suckling18John Suckling19John Suckling20Department of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomCalifornia Institute of Technology, Pasadena, CA, United StatesDepartment of Psychology, Columbia University, New York, NY, United StatesDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomCambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United KingdomBehavioural and Clinical Neuroscience Institute, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomBehavioural and Clinical Neuroscience Institute, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomInstitute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, United KingdomUniversity of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Oxford, Oxford, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomBehavioural and Clinical Neuroscience Institute, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomCambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United KingdomBehavioural and Clinical Neuroscience Institute, Cambridge, United KingdomCompared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD.http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/fulladolescent major depressive disorderaffective go/no-go taskcerebellumsupramarginal gyrussex difference |
| spellingShingle | Jie-Yu Chuang Cindy C. Hagan Cindy C. Hagan Cindy C. Hagan Graham K. Murray Graham K. Murray Graham K. Murray Julia M. E. Graham Cinly Ooi Roger Tait Rosemary J. Holt Rebecca Elliott Adrienne O. van Nieuwenhuizen Edward T. Bullmore Belinda R. Lennox Barbara J. Sahakian Barbara J. Sahakian Ian M. Goodyer John Suckling John Suckling John Suckling Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task Frontiers in Psychiatry adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference |
| title | Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task |
| title_full | Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task |
| title_fullStr | Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task |
| title_full_unstemmed | Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task |
| title_short | Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task |
| title_sort | adolescent major depressive disorder neuroimaging evidence of sex difference during an affective go no go task |
| topic | adolescent major depressive disorder affective go/no-go task cerebellum supramarginal gyrus sex difference |
| url | http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00119/full |
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