Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies
Chronic spontaneous urticaria (CSU) considerably alters patients’ quality of life, often for extended periods, due to pruriginous skin lesions, impaired sleep, unexpected development of angioedema, and failure of conventional treatments in properly controlling signs and symptoms. Recent research foc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/6/816 |
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| author | Olguța Anca Orzan Liliana Gabriela Popa Mara Mădălina Mihai Anca Cojocaru Călin Giurcăneanu Alexandra Maria Dorobanțu |
| author_facet | Olguța Anca Orzan Liliana Gabriela Popa Mara Mădălina Mihai Anca Cojocaru Călin Giurcăneanu Alexandra Maria Dorobanțu |
| author_sort | Olguța Anca Orzan |
| collection | DOAJ |
| description | Chronic spontaneous urticaria (CSU) considerably alters patients’ quality of life, often for extended periods, due to pruriginous skin lesions, impaired sleep, unexpected development of angioedema, and failure of conventional treatments in properly controlling signs and symptoms. Recent research focused on the development of new therapeutic agents with higher efficacy. Although the production of specific immunoglobulin E (IgE) antibodies against certain allergens is not a characteristic of the disease, treatment with omalizumab, a monoclonal anti-IgE antibody, proved efficient and safe in patients with moderate to severe chronic spontaneous urticaria uncontrolled by H1-antihistamines. Ligelizumab, a high-affinity monoclonal anti-IgE antibody, may also efficiently relieve symptoms of unresponsive chronic urticaria to standard therapies. This comprehensive review aims to present recently acquired knowledge on managing chronic spontaneous urticaria with new anti-IgE antibodies. We conducted extensive research on the main databases (PubMed, Google Scholar, and Web of Science) with no restrictions on the years covered, using the search terms “anti-IgE antibodies”, “omalizumab”, “ligelizumab”, and “chronic spontaneous urticaria”. The inclusion criteria were English written articles, and the exclusion criteria were animal-related studies. ClinicalTrials.gov was also reviewed for recent relevant clinical trials related to CSU treatment. CSU is a challenging disease with a significant effect on patients’ quality of life. Current therapies often fail to control signs and symptoms, and additional treatment is needed. New biologic therapies against IgE antibodies and FcεRIα receptors are currently under investigation in advanced clinical trials. We reviewed recently published data on CSU management using these novel treatments. The development of new and improved treatments for CSU will lead to a more personalized therapeutical approach for patients and provide guidance for physicians in better understanding disease mechanisms. However, some agents are still in clinical trials, and more research is needed to establish the safety and efficacy of these treatments. |
| first_indexed | 2024-03-09T23:06:15Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T23:06:15Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-ca288f61b07146558cd3ca39bb331f8d2023-11-23T17:53:04ZengMDPI AGMedicina1010-660X1648-91442022-06-0158681610.3390/medicina58060816Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE AntibodiesOlguța Anca Orzan0Liliana Gabriela Popa1Mara Mădălina Mihai2Anca Cojocaru3Călin Giurcăneanu4Alexandra Maria Dorobanțu5Dermatology Department, “Carol Davila” University of Medicine and Pharmacy, 011461 Bucharest, RomaniaDermatology Department, “Carol Davila” University of Medicine and Pharmacy, 011461 Bucharest, RomaniaDermatology Department, “Carol Davila” University of Medicine and Pharmacy, 011461 Bucharest, RomaniaDermatology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDermatology Department, “Carol Davila” University of Medicine and Pharmacy, 011461 Bucharest, RomaniaDermatology Department, “Elias” University Emergency Hospital, 011461 Bucharest, RomaniaChronic spontaneous urticaria (CSU) considerably alters patients’ quality of life, often for extended periods, due to pruriginous skin lesions, impaired sleep, unexpected development of angioedema, and failure of conventional treatments in properly controlling signs and symptoms. Recent research focused on the development of new therapeutic agents with higher efficacy. Although the production of specific immunoglobulin E (IgE) antibodies against certain allergens is not a characteristic of the disease, treatment with omalizumab, a monoclonal anti-IgE antibody, proved efficient and safe in patients with moderate to severe chronic spontaneous urticaria uncontrolled by H1-antihistamines. Ligelizumab, a high-affinity monoclonal anti-IgE antibody, may also efficiently relieve symptoms of unresponsive chronic urticaria to standard therapies. This comprehensive review aims to present recently acquired knowledge on managing chronic spontaneous urticaria with new anti-IgE antibodies. We conducted extensive research on the main databases (PubMed, Google Scholar, and Web of Science) with no restrictions on the years covered, using the search terms “anti-IgE antibodies”, “omalizumab”, “ligelizumab”, and “chronic spontaneous urticaria”. The inclusion criteria were English written articles, and the exclusion criteria were animal-related studies. ClinicalTrials.gov was also reviewed for recent relevant clinical trials related to CSU treatment. CSU is a challenging disease with a significant effect on patients’ quality of life. Current therapies often fail to control signs and symptoms, and additional treatment is needed. New biologic therapies against IgE antibodies and FcεRIα receptors are currently under investigation in advanced clinical trials. We reviewed recently published data on CSU management using these novel treatments. The development of new and improved treatments for CSU will lead to a more personalized therapeutical approach for patients and provide guidance for physicians in better understanding disease mechanisms. However, some agents are still in clinical trials, and more research is needed to establish the safety and efficacy of these treatments.https://www.mdpi.com/1648-9144/58/6/816anti-IgE antibodiesomalizumabligelizumabchronic spontaneous urticaria |
| spellingShingle | Olguța Anca Orzan Liliana Gabriela Popa Mara Mădălina Mihai Anca Cojocaru Călin Giurcăneanu Alexandra Maria Dorobanțu Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies Medicina anti-IgE antibodies omalizumab ligelizumab chronic spontaneous urticaria |
| title | Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies |
| title_full | Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies |
| title_fullStr | Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies |
| title_full_unstemmed | Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies |
| title_short | Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies |
| title_sort | current and future approaches in management of chronic spontaneous urticaria using anti ige antibodies |
| topic | anti-IgE antibodies omalizumab ligelizumab chronic spontaneous urticaria |
| url | https://www.mdpi.com/1648-9144/58/6/816 |
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