Cause of death during upper tract urothelial carcinoma survivorship: A contemporary, population-based analysis
BackgroundVery few studies have been published on the causes of death of upper tract urothelial carcinoma (UTUC). We sought to explore the mortality patterns of contemporary UTUC survivors.MethodsWe performed a retrospective cohort study involving patients with upper urinary tract carcinoma from the...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.948289/full |
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| author | Fu-Sheng Peng Wan-Ting Wu Lu Zhang Jia-Hua Shen Dong-Dong Yu Li-Qi Mao |
| author_facet | Fu-Sheng Peng Wan-Ting Wu Lu Zhang Jia-Hua Shen Dong-Dong Yu Li-Qi Mao |
| author_sort | Fu-Sheng Peng |
| collection | DOAJ |
| description | BackgroundVery few studies have been published on the causes of death of upper tract urothelial carcinoma (UTUC). We sought to explore the mortality patterns of contemporary UTUC survivors.MethodsWe performed a retrospective cohort study involving patients with upper urinary tract carcinoma from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database (2000 and 2015). We used standardized mortality ratios (SMRs) to compare death rates among patients with UTUC in the general population and excess absolute risks (EARs) to quantify the disease-specific death burden.ResultsA total of 10,179 patients with UTUC, including 7,133 who died, were included in our study. In total, 302 (17.17%) patients with the localized disease died of UTUC; however, patients who died from other causes were 4.8 times more likely to die from UTUC (n = 1,457 [82.83%]). Cardiovascular disease was the most common non-cancer cause of death (n = 393 [22.34% of all deaths]); SMR, 1.22; 95% confidence intervals [CI], 1.1–1.35; EAR, 35.96). A total of 4,046 (69.99%) patients with regional stage died within their follow-up, 1,413 (34.92%) of whom died from UTUC and 1,082 (26.74%) of whom died from non-cancer causes. UTUC was the main cause of death (SMR, 242.48; 95% CI, 230–255.47; EAR, 542.47), followed by non-tumor causes (SMR, 1.18; 95% CI, 1.11–1.25; EAR, 63.74). Most patients (94.94%) with distant stage died within 3 years of initial diagnosis. Although UTUC was the leading cause of death (n = 721 [54.29%]), these patients also had a higher risk of death from non-cancer than the general population (SMR, 2.08; 95% CI, 1.67–2.56; EAR, 288.26).ConclusionsNon-UTUC deaths accounted for 82.48% of UTUC survivors among those with localized disease. Patients with regional/distant stages were most likely to die of UTUC; however, there is an increased risk of dying from non-cancer causes that cannot be ignored. These data provide the latest and most comprehensive assessment of the causes of death in patients with UTUC. |
| first_indexed | 2024-04-12T01:11:28Z |
| format | Article |
| id | doaj.art-ca28ee0d2d204eca8cbd659d674db16b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T01:11:28Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-ca28ee0d2d204eca8cbd659d674db16b2022-12-22T03:54:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.948289948289Cause of death during upper tract urothelial carcinoma survivorship: A contemporary, population-based analysisFu-Sheng Peng0Wan-Ting Wu1Lu Zhang2Jia-Hua Shen3Dong-Dong Yu4Li-Qi Mao5Department of Urology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, ChinaMajor of Clinical Medicine, Huzhou University, Huzhou, ChinaMajor of Clinical Medicine, Huzhou University, Huzhou, ChinaDepartment of Medical Insurance Fund Supervision Section, Huzhou Wu-xing District Medical Insurance Management Service Center, Huzhou, ChinaDepartment of Urology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, ChinaDepartment of Gastroenterology, The First People‘s Hospital of Huzhou, First Affiliated Hospital of Huzhou University, Huzhou, ChinaBackgroundVery few studies have been published on the causes of death of upper tract urothelial carcinoma (UTUC). We sought to explore the mortality patterns of contemporary UTUC survivors.MethodsWe performed a retrospective cohort study involving patients with upper urinary tract carcinoma from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database (2000 and 2015). We used standardized mortality ratios (SMRs) to compare death rates among patients with UTUC in the general population and excess absolute risks (EARs) to quantify the disease-specific death burden.ResultsA total of 10,179 patients with UTUC, including 7,133 who died, were included in our study. In total, 302 (17.17%) patients with the localized disease died of UTUC; however, patients who died from other causes were 4.8 times more likely to die from UTUC (n = 1,457 [82.83%]). Cardiovascular disease was the most common non-cancer cause of death (n = 393 [22.34% of all deaths]); SMR, 1.22; 95% confidence intervals [CI], 1.1–1.35; EAR, 35.96). A total of 4,046 (69.99%) patients with regional stage died within their follow-up, 1,413 (34.92%) of whom died from UTUC and 1,082 (26.74%) of whom died from non-cancer causes. UTUC was the main cause of death (SMR, 242.48; 95% CI, 230–255.47; EAR, 542.47), followed by non-tumor causes (SMR, 1.18; 95% CI, 1.11–1.25; EAR, 63.74). Most patients (94.94%) with distant stage died within 3 years of initial diagnosis. Although UTUC was the leading cause of death (n = 721 [54.29%]), these patients also had a higher risk of death from non-cancer than the general population (SMR, 2.08; 95% CI, 1.67–2.56; EAR, 288.26).ConclusionsNon-UTUC deaths accounted for 82.48% of UTUC survivors among those with localized disease. Patients with regional/distant stages were most likely to die of UTUC; however, there is an increased risk of dying from non-cancer causes that cannot be ignored. These data provide the latest and most comprehensive assessment of the causes of death in patients with UTUC.https://www.frontiersin.org/articles/10.3389/fonc.2022.948289/fullcause of deathupper urinary tract carcinomastandardized mortality ratios (SMRs)excess absolute risks (EARs)surveillance epidemiology and end results (SEER) |
| spellingShingle | Fu-Sheng Peng Wan-Ting Wu Lu Zhang Jia-Hua Shen Dong-Dong Yu Li-Qi Mao Cause of death during upper tract urothelial carcinoma survivorship: A contemporary, population-based analysis Frontiers in Oncology cause of death upper urinary tract carcinoma standardized mortality ratios (SMRs) excess absolute risks (EARs) surveillance epidemiology and end results (SEER) |
| title | Cause of death during upper tract urothelial carcinoma survivorship: A contemporary, population-based analysis |
| title_full | Cause of death during upper tract urothelial carcinoma survivorship: A contemporary, population-based analysis |
| title_fullStr | Cause of death during upper tract urothelial carcinoma survivorship: A contemporary, population-based analysis |
| title_full_unstemmed | Cause of death during upper tract urothelial carcinoma survivorship: A contemporary, population-based analysis |
| title_short | Cause of death during upper tract urothelial carcinoma survivorship: A contemporary, population-based analysis |
| title_sort | cause of death during upper tract urothelial carcinoma survivorship a contemporary population based analysis |
| topic | cause of death upper urinary tract carcinoma standardized mortality ratios (SMRs) excess absolute risks (EARs) surveillance epidemiology and end results (SEER) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.948289/full |
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