Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma
We applied modern molecular and functional imaging to the pretreatment assessment of lung cancer using combined dynamic contrast-enhanced computed tomography (DCE-CT) and 18 F-fluorodeoxyglucose–positron emission tomography ( 18 F-FDG-PET) to phenotype tumors. Seventy-four lung cancer patients were...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2012-09-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2011.00052 |
| _version_ | 1826910946904244224 |
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| author | Manu Shastry Kenneth A. Miles Thida Win Sam M. Janes Raymond Endozo Marie Meagher Peter J. Ell Ashley M. Groves |
| author_facet | Manu Shastry Kenneth A. Miles Thida Win Sam M. Janes Raymond Endozo Marie Meagher Peter J. Ell Ashley M. Groves |
| author_sort | Manu Shastry |
| collection | DOAJ |
| description | We applied modern molecular and functional imaging to the pretreatment assessment of lung cancer using combined dynamic contrast-enhanced computed tomography (DCE-CT) and 18 F-fluorodeoxyglucose–positron emission tomography ( 18 F-FDG-PET) to phenotype tumors. Seventy-four lung cancer patients were prospectively recruited for 18 F-FDG-PET/DCE-CT using PET/64-detector CT. After technical failures, there were 64 patients (35 males, 29 females; mean age [± SD] 67.5 ± 7.9 years). DCE-CT yielded tumor peak enhancement (PE) and standardized perfusion value (SPV). The uptake of 18 F-FDG quantified on PET as the standardized uptake value (SUV max ) assessed tumor metabolism. The median values for SUV max and SPV were used to define four vascular-metabolic phenotypes. There were associations (Spearman rank correlation [ rs ]) between tumor size and vascular-metabolic parameters: SUV max versus size ( rs = .40, p = .001) and SUV/PE versus size ( r = .43, p < .001). Patients with earlier-stage (1-HA, n = 30) disease had mean (± SD) SUV/PE 0.36 ± 0.28 versus 0.56 ± 0.32 in later-stage (stage IIB-IV, n = 34) disease ( p = .007). The low metabolism with high vascularity phenotype was significantly more common among adenocarcinomas ( p = .018), whereas the high metabolism with high vascularity phenotype was more common among squamous cell carcinomas ( p = .024). Other non-small cell lung carcinoma tumor types demonstrated a high prevalence of the high metabolism with low vascularity phenotype ( p = .028). We show that tumor subtypes have different vascular-metabolic associations, which can be helpful clinically in managing lung cancer patients to hone targeted therapy. |
| first_indexed | 2024-03-07T17:22:32Z |
| format | Article |
| id | doaj.art-ca294ed80b2347f08c55e2306e8206a9 |
| institution | Directory Open Access Journal |
| issn | 1536-0121 |
| language | English |
| last_indexed | 2025-02-17T10:08:23Z |
| publishDate | 2012-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj.art-ca294ed80b2347f08c55e2306e8206a92025-01-02T02:58:05ZengSAGE PublishingMolecular Imaging1536-01212012-09-011110.2310/7290.2011.0005210.2310_7290.2011.00052Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung CarcinomaManu ShastryKenneth A. MilesThida WinSam M. JanesRaymond EndozoMarie MeagherPeter J. EllAshley M. GrovesWe applied modern molecular and functional imaging to the pretreatment assessment of lung cancer using combined dynamic contrast-enhanced computed tomography (DCE-CT) and 18 F-fluorodeoxyglucose–positron emission tomography ( 18 F-FDG-PET) to phenotype tumors. Seventy-four lung cancer patients were prospectively recruited for 18 F-FDG-PET/DCE-CT using PET/64-detector CT. After technical failures, there were 64 patients (35 males, 29 females; mean age [± SD] 67.5 ± 7.9 years). DCE-CT yielded tumor peak enhancement (PE) and standardized perfusion value (SPV). The uptake of 18 F-FDG quantified on PET as the standardized uptake value (SUV max ) assessed tumor metabolism. The median values for SUV max and SPV were used to define four vascular-metabolic phenotypes. There were associations (Spearman rank correlation [ rs ]) between tumor size and vascular-metabolic parameters: SUV max versus size ( rs = .40, p = .001) and SUV/PE versus size ( r = .43, p < .001). Patients with earlier-stage (1-HA, n = 30) disease had mean (± SD) SUV/PE 0.36 ± 0.28 versus 0.56 ± 0.32 in later-stage (stage IIB-IV, n = 34) disease ( p = .007). The low metabolism with high vascularity phenotype was significantly more common among adenocarcinomas ( p = .018), whereas the high metabolism with high vascularity phenotype was more common among squamous cell carcinomas ( p = .024). Other non-small cell lung carcinoma tumor types demonstrated a high prevalence of the high metabolism with low vascularity phenotype ( p = .028). We show that tumor subtypes have different vascular-metabolic associations, which can be helpful clinically in managing lung cancer patients to hone targeted therapy.https://doi.org/10.2310/7290.2011.00052 |
| spellingShingle | Manu Shastry Kenneth A. Miles Thida Win Sam M. Janes Raymond Endozo Marie Meagher Peter J. Ell Ashley M. Groves Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma Molecular Imaging |
| title | Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma |
| title_full | Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma |
| title_fullStr | Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma |
| title_full_unstemmed | Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma |
| title_short | Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma |
| title_sort | integrated f fluorodeoxyglucose positron emission tomography dynamic contrast enhanced computed tomography to phenotype non small cell lung carcinoma |
| url | https://doi.org/10.2310/7290.2011.00052 |
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