A hierarchical generative framework of language processing: Linking language perception, interpretation, and production abnormalities in schizophrenia
Language and thought dysfunction are central to the schizophrenia syndrome. They are evident in the major symptoms of psychosis itself, particularly as disorganized language output (positive thought disorder) and auditory verbal hallucinations, and they also manifest as abnormalities in both high-le...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-11-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00643/full |
| _version_ | 1819105788399976448 |
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| author | Meredith eBrown Meredith eBrown Gina R Kuperberg Gina R Kuperberg |
| author_facet | Meredith eBrown Meredith eBrown Gina R Kuperberg Gina R Kuperberg |
| author_sort | Meredith eBrown |
| collection | DOAJ |
| description | Language and thought dysfunction are central to the schizophrenia syndrome. They are evident in the major symptoms of psychosis itself, particularly as disorganized language output (positive thought disorder) and auditory verbal hallucinations, and they also manifest as abnormalities in both high-level semantic and contextual processing and low-level perception. However, the literatures characterizing these abnormalities have largely been separate and have sometimes provided mutually exclusive accounts of aberrant language in schizophrenia. In this review, we propose that recent generative probabilistic frameworks of language processing can provide crucial insights that link these four lines of research. We first outline neural and cognitive evidence that real-time language comprehension and production normally involve internal generative circuits that propagate probabilistic predictions to perceptual cortices — predictions that are incrementally updated based on prediction error signals as new inputs are encountered. We then explain how disruptions to these circuits may compromise communicative abilities in schizophrenia by reducing the efficiency and robustness of both high-level language processing and low-level speech perception. We also argue that such disruptions may contribute to the phenomenology of thought-disordered speech and false perceptual inferences in the language system (i.e., auditory verbal hallucinations). This perspective suggests a number of productive avenues for future research that may elucidate not only the mechanisms of language abnormalities in schizophrenia, but also promising directions for cognitive rehabilitation. |
| first_indexed | 2024-12-22T02:27:49Z |
| format | Article |
| id | doaj.art-ca2a36aba53f49ca8538843a106763b9 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T02:27:49Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-ca2a36aba53f49ca8538843a106763b92022-12-21T18:41:57ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-11-01910.3389/fnhum.2015.00643159808A hierarchical generative framework of language processing: Linking language perception, interpretation, and production abnormalities in schizophreniaMeredith eBrown0Meredith eBrown1Gina R Kuperberg2Gina R Kuperberg3Massachusetts General HospitalTufts UniversityMassachusetts General HospitalTufts UniversityLanguage and thought dysfunction are central to the schizophrenia syndrome. They are evident in the major symptoms of psychosis itself, particularly as disorganized language output (positive thought disorder) and auditory verbal hallucinations, and they also manifest as abnormalities in both high-level semantic and contextual processing and low-level perception. However, the literatures characterizing these abnormalities have largely been separate and have sometimes provided mutually exclusive accounts of aberrant language in schizophrenia. In this review, we propose that recent generative probabilistic frameworks of language processing can provide crucial insights that link these four lines of research. We first outline neural and cognitive evidence that real-time language comprehension and production normally involve internal generative circuits that propagate probabilistic predictions to perceptual cortices — predictions that are incrementally updated based on prediction error signals as new inputs are encountered. We then explain how disruptions to these circuits may compromise communicative abilities in schizophrenia by reducing the efficiency and robustness of both high-level language processing and low-level speech perception. We also argue that such disruptions may contribute to the phenomenology of thought-disordered speech and false perceptual inferences in the language system (i.e., auditory verbal hallucinations). This perspective suggests a number of productive avenues for future research that may elucidate not only the mechanisms of language abnormalities in schizophrenia, but also promising directions for cognitive rehabilitation.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00643/fullLanguageSchizophreniaSpeech PerceptionAuditory verbal hallucinationsGenerative modelsthought disorder |
| spellingShingle | Meredith eBrown Meredith eBrown Gina R Kuperberg Gina R Kuperberg A hierarchical generative framework of language processing: Linking language perception, interpretation, and production abnormalities in schizophrenia Frontiers in Human Neuroscience Language Schizophrenia Speech Perception Auditory verbal hallucinations Generative models thought disorder |
| title | A hierarchical generative framework of language processing: Linking language perception, interpretation, and production abnormalities in schizophrenia |
| title_full | A hierarchical generative framework of language processing: Linking language perception, interpretation, and production abnormalities in schizophrenia |
| title_fullStr | A hierarchical generative framework of language processing: Linking language perception, interpretation, and production abnormalities in schizophrenia |
| title_full_unstemmed | A hierarchical generative framework of language processing: Linking language perception, interpretation, and production abnormalities in schizophrenia |
| title_short | A hierarchical generative framework of language processing: Linking language perception, interpretation, and production abnormalities in schizophrenia |
| title_sort | hierarchical generative framework of language processing linking language perception interpretation and production abnormalities in schizophrenia |
| topic | Language Schizophrenia Speech Perception Auditory verbal hallucinations Generative models thought disorder |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00643/full |
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